Spike protein
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FunctionThe coronavirus spike protein (Spi, also called protein S) binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus [1]. See also
DiseaseNumerous viral diseases are causing world-shattering consequences and the current pandemic of CoVID-2019 is the recent one. RelevanceThe spike protein is a key target for potential therapies and diagnostics. Various antibodies are currently being tested as potential CoVID-2019 antiviral treatment[2]. Structural highlightsThe SARS-CoV Spi receptor binding domain complex with its cellular receptor - ACE2 - shows the to ACE2 "hot spot"[3]. See Also
3D Structures of spike proteinReferences
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Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Eric Martz, Joel L. Sussman
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