Phosphodiesterase 3D structures

3D Structures of phosphodiesterase

Updated on 05-May-2026

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• cAMP PDE
  • 1loi – rPDE N terminal – rat – NMR
    
  • 3ib7 – MtPDE – Mycobacterium tuberculosis
    
  • 3ib8 – MtPDE + AMP
• cGMP PDE or cyclic di-GMP PDE
  • 1ksg, 1ksh, 1ksj – hPDE δ subunit + ARF-like protein - human
    
  • 2ju4 - bPDE γ subunit – bovine - NMR
    
  • 6mzb - bPDE α,β,γ subunits – Cryo EM
    
  • 4kie, 4lyk - EcPDE EAL domain 96-372 – Escherichia coli
    
  • 7pk5 - EcPDE 2-362
    
  • 4lj3 - EcPDE EAL domain + GMP
    
  • 4r8z - PaPDE HD-GYP domain + Ni – Pseudomonas aeruginosa
    
  • 2bas – BsYkuI – Bacillus subtilis
    
  • 2w27 – BsYkuI + C-di-GMP
  • 3gfx, 3gfy, 3gfz, 3gg0, 3gg1 – KpBlrP1 + C-di-GMP - Klebsiella pneumoniae
    
  • 2kb2 - KpBlrP1 BLUF domain - NMR
• PDE 1
  • 4ojv – yPDE – yeast
    
  • 4ojx – yPDE + GMP
    
  • 5ijj – PDE SPX domain 1-184 + INSP6 – Chaetomium thermophilum
    
• PDE 1b or calcium/calmodulin-dependent 3’,5’-cyclic PDE
  • 1taz – hPDE 1b catalytic domain – human
    
  • 4npv, 4npw, 5uoy, 5up0, 5w6e - hPDE 1b catalytic domain + inhibitor
    
  • 5b25 - hPDE 1b catalytic domain (mutant) + inhibitor
    
  • 2r8q - PDE 1b catalytic domain + inhibitor – Leishmania major
    
• PDE 2A or cGMP-dependent 3’,5’-cyclic PDE
  • 1f0j – mPDE 2a regulatory domain (mutant) – mouse
    
  • 1z1l, 3ibj, 3itm - hPDE 2a catalytic domain
    
  • 3itu, 4c1i, 4d08, 4d09, 4htx, 4htz, 4jib, 5tz3, 5tza, 5tzc, 5tzh, 5tzw, 5tzx, 5tzz, 5u00, 5u70, 5u7d, 5u7i, 5u7j, 5u7k, 5vp0, 5vp1, 5xkm, 6b96, 6b97, 6b98, 6blf, 6c7d, 6c7e, 6c7f, 6c7g, 6c7i, 6c7j, 6cyb, 6cyc, 6cyd, 6ezf, 6znd, 9wp3 - hPDE 2a catalytic domain + inhibitor
    
  • 1f0j – mPDE 2a regulatory domain (mutant) – mouse
    
  • 6cpu - CaPDE 2 – Candida albicans
    
  • 6cpt - CaPDE 2 + IBMX
    
• PDE 2H or RNA 2’,3’-cyclic PDE
  • 5ldi - EcPDE
    
  • 5ldq - EcPDE + NADP
    
  • 5ldk, 5ldm, 5ldo, 5ldp - EcPDE + nucleotide
    
  • 5ldj - EcPDE + Pi
    
  • 5h7e, 5h7f - PDE core domain – Deinococcus radiodurans
    
• PDE 3
  • 7l27 – hPDE 3a
    
  • 7l29 – hPDE 3a + AMP
    
  • 7kwe – hPDE 3a + DNMDP
    
  • 7l28 – hPDE 3a + trequinsin
    
  • 7eg0, 7eg1, 7eg4, 7lrc, 7lrd – hPDE 3a + SLFN12 – Cryo EM
    
  • 1so2, 1soj, 8syc, 9yud – hPDE 3b catalytic domain + inhibitor
    
  • 5z7c – PDE 3 (mutant) – Vibrio cholerae
    
• PDE 4a
  • 3i8v, 3tvx – hPDE 4a catalytic domain + inhibitor
    
  • 6fg5, 6ezu - PDE 4a residues 230-597 – Schistosoma mansoni
    
• PDE 4b or cAMP-specific 3’,5’-cyclic PDE
  • 1f0j, 4wzi– hPDE 4b catalytic domain (mutant)
    
  • 1ro6, 1xmy, 1xn0 - hPDE 4b catalytic domain + anti-inflammatory drug
    
  • 1xot - hPDE 4b catalytic domain + drug
    
  • 1tb5, 1ro9, 1ror - hPDE 4b catalytic domain + AMP
    
  • 1y2h, 1y2j, 2qyl, 3d3p, 3kkt, 3frg, 3gwt, 3ly2, 3hmv, 3o56, 3o57, 3o0j, 3w5e, 3wd9, 4myq, 4kp6, 4nw7, 5k6j, 5ohj, 5laq, 8oeg - hPDE 4b catalytic domain + inhibitor
    
  • 4x0f - hPDE 4b catalytic domain (mutant) + inhibitor
    
  • 3g45 - hPDE 4b catalytic domain + modulator
• PDE 4c
  • 2qym – hPDE 4c catalytic domain
• PDE 4d or cAMP-specific 3’5’-cyclic PDE 4d
  • 1e9k - hPDE 4d5 N terminal – NMR
    
  • 1mkd, 1oyn, 1q9m, 1tbb, 1xoq, 3g4k, 3g4l - hPDE 4d catalytic domain + anti-inflammatory drug
    
  • 1xlx, 1xlz, 1xm4, 1xm6, 1xmu, 1xom, 1xon, 1xor, 1xos, 3iak, 6akr, 6kjz, 6kk0, 6lrm, 7cbq - hPDE 4d catalytic domain + drug
    
  • 1ptw, 1tb7 - hPDE 4d catalytic domain + AMP
    
  • 2pw3 - hPDE 4d catalytic domain (mutant) + AMP
    
  • 1y2b, 1y2c, 1y2d, 1y2e, 1y2k, 1zkn, 2fm0, 2fm5, 2qyn, 3k4s, 3sl3, 3sl4, 3sl5, 3sl6, 3sl8, 3v9b, 4ogb, 4w1o, 4wcu, 5k1i, 5k32, 5lbo, 5tkb, 5wh5, 5wh6, 5wqa, 6boj, 6f6u, 6f8r, 6f8t, 6f8u, 6f8v, 6f8w, 6f8x, 6fdc, 6fdi, 6fe7, 6feb, 6fet, 6ft0, 6fta, 6ftw, 6fw3, 6hwo, 6iag, 6ibf, 6im6, 6imb, 6imd, 6imi, 6imo, 6imr, 6imt, 6ind, 6ink, 6inm, 6rcw, 6zba, 7a8q, 7a9v, 7aag, 7ab9, 7abd, 7abe, 7abj, 7ay6, 7b9h, 7cbj, 7f2k, 7f2l, 7f2m, 7w4x, 7w4y, 7xaa, 7xab, 7xbb, 7yqf, 7ysx, 8k4c, 8k4h, 8w4q, 8w4r, 8wdn, 8wdo, 8xxs - hPDE 4d catalytic domain + inhibitor
    
  • 6njj, 6nji, 6njh - hPDE 4d catalytic domain (mutant) + inhibitor
    
  • 3iad, 3g4g, 3g4i, 3g58 - hPDE 4d catalytic domain + modulator
• PDE 5 or cGMP-specific 3’,5’-cyclic PDE
  • 2h40 - hPDE 5a catalytic domain
    
  • 1t9r - hPDE 5 catalytic domain
    
  • 3lfv, 3mf0, 2xss - hPDE 5a GAF domain
    
  • 1rkp, 3tgg – hPDE 5a1 catalytic domain (mutant) + inhibitor
    
  • 2chm, 4oex, 4oew, 4g2w, 4g2y, 4i9z, 4ia0, 4md6, 5jo3, 6acb, 5zz2, 6iwi, 6vbi, 7far - hPDE 5a catalytic domain + inhibitor
    
  • 2h44, 3bjc, 3hc8, 3hdz, 3shy, 3shz, 3sie, 3tge, 8w4s, 8w4t, 8wkf, 8wkg, 8xww, 9lsl, 9lsm, 9lss - hPDE 5a1 catalytic domain + inhibitor
    
  • 1udt, 1udu, 1uho, 1tbf, 1xoz, 1xp0, 2h42, 3b2r, 6l6e - hPDE 5 catalytic domain + drug
    
  • 3jwq - hPDE 5/hPDE 6 catalytic domain + drug
    
  • 3jwr - hPDE 5/hPDE 6 catalytic domain + hPDE γ subunit peptide + inhibitor
    
  • 1t9s - hPDE 5 catalytic domain + GMP
    
  • 2k31 - mPDE 5a cGMP-binding domain – NMR
    
  • 5w10 - PDE + cAMP – Leptospira interrogans
    
• PDE 6 or retinal rod rhodopsin-sensitive cGMP 3’,5’-cyclic PDE
  • 9cxg, 9cxi, 9csj - hPDE 6c alpha’ subunit + cone P gamma – Cryo EM
    
  • 9cxh - hPDE 6c alpha’ subunit + cone P gamma + GMP – Cryo EM
    
  • 5t4x, 7pac, 7q9q - hPDE 6d δ subunit
    
  • 3t5g – hPDE 6d δ subunit + GTP-binding protein RHEB
    
  • 3t5i - hPDE 6d δ subunit + GTP-binding protein RHEB peptide
    
  • 5tar, 5tb5, 7q9u - hPDE 6d δ subunit + GTP-binding protein KRas
    
  • 7qf9 - hPDE 6d δ subunit + KRas peptide
    
  • 7q9s - hPDE 6d δ subunit + KRas peptide + inhibitor
    
  • 7q9r - hPDE 6d δ subunit + NRas peptide
    
  • 5f2u - hPDE 6d δ subunit + INPP5E peptide
    
  • 5e8f - hPDE 6d δ subunit + PDE 6c peptide
    
  • 4jhp - hPDE 6d δ subunit + RPGR
    
  • 4jv6, 4jv8, 4jvb, 4jvf, 5e80, 5ml2, 5ml3, 5ml4, 5ml6, 5ml8, 5nal, 5x72, 5x73, 5x74, 5yav, 5yaw, 7faq, 7pad, 7pae, 7qjk, 9hmc, 9hmd, 9rp6, 9rp7 - hPDE 6d δ subunit + inhibitor
    
  • 9dww - hPDE 6d δ subunit + cereblon + DDBP 1 + inhibitor – Cryo EM
    
  • 6mzb, 7jsn - bPDE 6 g subunit in visual signaling complex – Cryo EM
    
  • 8ufi - bPDE 6 alpha+beta+gamma – Cryo EM
    
  • 8ugs - bPDE 6 alpha+beta+gamma + cGMP – Cryo EM
    
  • 8ulg - bPDE 6 alpha+beta+gamma + xanthine derivative – Cryo EM
    
  • 8ugb - bPDE 6 alpha+beta+gamma + drug – Cryo EM
    
  • 3dba - cPDE 6c GAF A domain – chicken
    
  • 6x88 - cPDE 6c a subunit GAF domain 1-862
    
• PDE 7
  • 1zkl, 3g3n, 2y2b, 4y2b, 4pm0 – hPDE 7a catalytic domain + inhibitor
    
• PDE 8
  • 3ecm – hPDE 8a catalytic domain
    
  • 3ecn, 7cwf, 7cwg, 7vsl, 7vtv, 7vtw, 7vtx, 8yta – hPDE 8a catalytic domain + inhibitor
    
  • 7cwa - hPDE 8a catalytic domain + leukemia drug
    
• PDE 9
  • 2hd1, 2yy2, 3jsi, 3jsw, 3k3e, 3k3h, 4e90, 4g2j, 4g2l, 4gh6,4y8c, 4y87, 4y86, 6a3n, 6lzz, [[[7f0i]], [8bpy]] - hPDE 6d δ subunit + RPGR
    
  • 8bpy - hPDE 9a catalytic domain + inhibitor
    
  • 3n3z, 3qi3, 3qi4 - hPDE 9a catalytic domain (mutant) + inhibitor
    
  • 3dy8, 3dyl, 3dyn, 3dyq, 3dys - hPDE 9 catalytic domain + GMP
    
  • 4qge - PDE 9 catalytic domain + inhibitor - chimpanzee
    
  • 4gyz - mPDE 9 catalytic domain + AMP
    
• PDE 10 or cAMP and cAMP-inhibited cGMP 3’,5’-cyclic PDE
  • 2oup, 5sjh - hPDE 10a catalytic domain
    
  • 2zmf – hPDE 10a C terminal
    
  • 2ous, 2ouv - hPDE 10a2 catalytic domain (mutant)
    
  • 2qyk, 2y0j, 3lxg, 3qpn, 3qpo, 3qpp, 3sn7, 3sni, 3snl, 3wi2, 3ws8, 3ws9, 3wyk, 3wyl, 3wym, 4ael, 4ajd, 4ajf, 4ajg, 4ajm, 4ddl, 4fcb, 4fcd, 4heu, 4hf4, 4lkq, 4llj, 4llk, 4llp, 4llx, 4lm0, 4lm1, 4lm2, 4lm3, 4lm4, 4mrw, 4mrz, 4ms0, 4msa, 4msc, 4mse, 4msh, 4msn, 4muw, 4mvh, 4p0n, 4p1r, 4phw, 4tpm, 4tpp, 4wn1, 4xy2, 4yqh, 4ys7, 4zo5, 5axp, 5axq, 5b4k, 5b4l, 5c1w, 5c28, 5c29, 5c2a, 5c2e, 5c2h, 5dh4, 5dh5, 5ede, 5edg, 5edh, 5edi, 5k9r, 5i2r, 5sdu, 5sdv, 5sdw, 5sdx, 5sdy, 5sdz, 5se0, 5se1, 5se2, 5se3, 5se4, 5se5, 5se6, 5se7, 5se8, 5se9, 5sea, 5seb, 5sec, 5sed, 5see, 5sef, 5seg, 5seh, 5sei, 5sej, 5sek, 5sel, 5sem, 5sen, 5seo, 5sep, 5seq, 5ser, 5ses, 5set, 5seu, 5sev, 5sew, 5sex, 5sey, 5sez, 5sf0, 5sf1, 5sf2, 5sf3, 5sf4, 5sf5, 5sf6, 5sf7, 5sf8, 5sf9, 5sfa, 5sfb, 5sfc, 5sfd, 5sfe, 5sff, 5sfg, 5sfh, 5sfi, 5sfj, 5sfk, 5sfl, 5sfm, 5sfn, 5sfo, 5sfp, 5sfq, 5sfs, 5sft, 5sfu, 5sfv, 5sfw, 5sfx, 5sfy, 5sfz, 5sg0, 5sg1, 5sg2, 5sg3, 5sg4, 5sg5, 5sg6, 5sg7, 5sg8, 5sg9, 5sgc, 5sgb, 5sgd, 5sge, 5sgf, 5sgg, 5sgh, 5sgi, 5sgj, 5sgk, 5sgl, 5sgm, 5sgn, 5sgo, 5sgp, 5sgq, 5sgr, 5sgs, 5sgt, 5sgu, 5sgv, 5sgw, 5sgx, 5sgy, 5sgz, 5sh0, 5sh1, 5sh2, 5sh3, 5sh4, 5sh5, 5sh6, 5sh7, 5sh8, 5sh9, 5sha, 5shb, 5shc, 5shd, 5she, 5shf, 5shg, 5shh, 5shi, 5shj, 5shk, 5shl, 5shm, 5shn, 5sho, 5shp, 5shq, 5shr, 5shs, 5sht, 5shu, 5shv, 5shw, 5shx, 5shy, 5shz, 5si0, 5si1, 5si2, 5si3, 5si4, 5si5, 5si6, 5si7, 5si8, 5si9, 5sia, 5sib, 5sid, 5sie, 5sif, 5sig, 5sih, 5sii, 5sij, 5sik, 5sil, 5sim, 5sin, 5sio, 5sip, 5sir, 5sis, 5sit, 5siu, 5siv, 5siw, 5six, 5siy, 5siz, 5sj0, 5sj1, 5sj3, 5sj4, 5sj5, 5sj6, 5sj7, 5sj8, 5sj9, 5sja, 5sjb, 5sjc, 5sjd, 5sje, 5sjf, 5sjg, 5sji, 5sjj, 5sjk, 5sjl, 5sjm, 5sjo, 5sjp, 5sjq, 5sjr, 5sjs, 5sjt, 5sju, 5sjv, 5sjx, 5sjy, 5sjz, 5sk0, 5sk1, 5sk2, 5sk3, 5sk4, 5sk5, 5sk7, 5sk8, 5sk9, 5ska, 5skb, 5skc, 5skd, 5ske, 5skf, 5skg, 5skh, 5ski, 5skj, 5skk, 5skl, 5skm, 5skn, 5sko, 5skp, 5skq, 5skr, 5sks, 5skt, 5sku, 5skv, 5uwf, 5xui, 5xuj, 5znl, 6ijh, 6iji, 6ko0, 6ko1, 6kze, 6msa, 6msc, 7bpi, 7qpm, 8xv3, 9ja8, 9jdu, 9vq3 - hPDE 10a catalytic domain + inhibitor
    
  • 2wey, 3hqw, 3hqy, 3hqz, 3hr1, 3ui7, 3uuo, 4bbx, 4dff, 8di4 - hPDE 10a catalytic domain + schizophrenia drug
    
  • 2oun - hPDE 10a2 catalytic domain + AMP
    
  • 2our, 2ouy - hPDE 10a2 catalytic domain (mutant) + AMP
    
  • 2ouq - hPDE 10a2 catalytic domain + GMP
    
  • 2ouu - hPDE 10a2 catalytic domain (mutant) + GMP
    
  • 2o8h – rPDE 10a catalytic domain
    
  • 6k9u, 2ovv, 2ovy - rPDE 10a catalytic domain + inhibitor
    
• PDE 12
  • 4zkf, 4z0v - hPDE
    
  • 4z2b - hPDE + inhibitor
    
• PDE b1
  • 4i15 – TbPDEb1 catalytic domain – Trypanosoma brucei
    
  • 5l9h, 5l8y, 5l8c, 5g5v, 5g57, 5g2b, 4phl, 6rgk, 6rfw, 6rfn, 6rb6, 6gxq, 6fv9, 6ftm, 6frd, 6fe3, 6fdx, 6fdw, 6fds, 6qgp, 6qgu, 7a28, 7a2f – TbPDEb1 catalytic domain + inhibitor
    
• PDE b2
  • 5h2r, 5h2q – TbPDEb2 catalytic domain + inhibitor
    
• U6 snRNA PDE
  • 5v1m - hPDE + UMP
    
  • 6d31 - hPDE + AMP
    
  • 6d2z, 6d30 - hPDE (mutant) + RNA
    
  • 5uqj - yPDE
    
  • 6pfq, 6pgl - PDE - Kluyveromyces marxianus
    
• Diguanylate PDE
  • 5mkg, 5mf5 - PaPDE + c-di-GMP
    
  • 5mfu - PaPDE + GMP + Mn
    
  • 5m1t - PaPDE + c-di-GMP + Mg
    
• PDE PgpH
  • 4s1c - LmPDE HD domain 494-715 – Listeria monocytogenes
    
  • 4s1b - LmPDE HD domain + c-di-AMP
    
• Zinc PDE ELAC protein 2 or ELAC2
  • 3zwf - hPDE
    
  • 8z0p – hPDE – Cryo EM
    
  • 8z1f, 8z1g - hPDE + tRNA-Tyr – Cryo EM
    , 9ey2
  • 8cbl, 9ey0, 9ey1 - hPDE in RNase Z complex – Cryo EM
    
  • 8rr1, 8rr3, 8rr4 - hPDE (mutant) in RNase Z complex – Cryo EM
    
• Sphingomyelin PDE see Sphingomyelinase
• 1-phosphatidylinositol PDE see Phospholipase C
• C-di-GMP PDE See C-di-GMP specific phosphodiesterases
• 2’3’-cyclic-nucleotide 3’-PDE
  • 1woj – hPDE residues 166-379
    
  • 2ilx - rPDE catalytic domain
    
  • 2xmi, 2y1p, 2y3x, 5ae0 - mPDE catalytic domain
    
  • 4wbi, 4wbl, 4wd9, 4wcc, 4wcd, 4wce, 4wch, 4wex, 7qzk, 7qzs - mPDE catalytic domain (mutant)
    
  • 2ydb - mPDE catalytic domain + cyclic NADP
    
  • 3zbr, 3zbs, 3zbz - mPDE catalytic domain (mutant) + NADP
    
  • 2ydc - mPDE catalytic domain + GTP
    
  • 2ydd - mPDE catalytic domain + cyclic AMP
    
  • 2ypc, 2ype, 2yph - mPDE catalytic domain (mutant) + cyclic AMP
    
  • 2yoz, 2yp0, 4wfr - mPDE catalytic domain + 2’-AMP
    
  • 2yq9, 4wda, 4wdb - mPDE catalytic domain (mutant) + 2’-AMP
    
  • 4wdf, 4wdg - mPDE catalytic domain (mutant) + 2’-ADP
    
  • 9ert, 9eru, 9erw, 9etj, 9etl - mPDE catalytic domain + nanobody
    
  • 1fsi, 1jh6 – AtPDE – Arabidopsis thaliana
    
  • 1jh7 – AtPDE + inhibitor
    
  • 3jyf – KpPDE residues 16-354
    
  • 3v93 – TcPDE catalytic domain – Trypanosoma cruzi
    
  • 3v94 - TcPDE catalytic domain + inhibitor
    
• 3’5’-cyclic-nucleotide 3’-PDE
  • 8ylc, 8zq1, 8zq2, 8zqu, 8zqw – hPDE + drug
    
  • 9lo7, 9lro, 9lrp, 9wp5 – hPDE + inhibitor
    
  • 1mc0 – mPDE regulatory subunit
    
• Tyrosyl-DNA PDE
  • 1jy1, 1qzq – hPDE1 catalytic domain
    
  • 1mu7 - hPDE1 catalytic domain (mutant) + WO4
    
  • 1mu9 - hPDE1 catalytic domain (mutant) + VO4
    
  • 1nop, 1rff, 1rfi, 1rg1, 1rg2, 1rgt - hPDE1 catalytic domain (mutant) + DNA + topoisomerase peptide + VO4
    
  • 1rgu, 1rh0 - hPDE1 catalytic domain (mutant) + polynucleotide + neurohormone
    
  • 6dhu, 6die, 6dih, 6dim, 6djd, 6dje, 6djf, 6djg, 6djh, 6dji, 6djj, 6mj5, 6myz, 6mz0, 6n0d, 6n0n, 6n0o, 6n0r, 6n17, 6n19, 6w4r, 6w7j, 6w7k, 6w7l, 7ufy, 7ufz, 8cvq, 8cw2, 8uv1, 8uzv, 8uzz, 8v0b, 8v0c, 9b3b - hPDE catalytic domain + inhibitor
    
  • 5j3s, 5j3p - hPDE catalytic domain (mutant) + inhibitor
    
  • 5nwa, 5nw9 – hPDE1 residues 1-148 + DNA
    
  • 6q00, 6q01 - hPDE UBA domain 25-66 + ubiquitin
    
  • 5j3s, 5j3p - hPDE1 catalytic domain (mutant) + inhibitor
    
  • 5inm - mPDE catalytic domain
    
  • 5inn - mPDE catalytic domain (mutant)
    
  • 4gz0, 4gz1, 4gz2, 4puq, 5inq, 5inp, 5ino, 5inl, 5ink, 5ht2 – mPDE catalytic domain + DNA
    
  • 5tvq – mPDE catalytic domain + SUMO-2
    
  • 5tvp – mPDE catalytic domain + SUMO-2 + DNA
    
  • 5j42, 5j3z - mPDE catalytic domain (mutant) + inhibitor
    
  • 4f1h, 4fpv – zPDE + DNA – zebra fish
    
  • 6ca4 - zPDE catalytic domain (mutant) + inhibitor
    
  • 4f1i, 4fva, 4gew – PDE – Caenorhabditis elegans
    
  • 1q32 – yPDE
    
  • 3sq3, 3sq5, 3sq7, 3sq8 – yPDE (mutant)
    
• Glycerophosphodiester PDE
  • 1o1z – TmPDE – Thermotoga maritima
    
  • 1t8q, 1ydy – EcPDE
    
  • 1v8e – TtPDE – Thermus thermophilus
    
  • 1vd6 – TtPDE + glycerol
    
  • 1zcc – PDE – Agrobacterium tumefaciens
    
  • 2o55 – PDE – Galdieria sulphuraria
    
  • 2oog, 2p76, 8ghh, 8ghi – SaPDE – Staphylococcus aureus
    
  • 2otd – PDE – Shigella flexneri
    
  • 3ch0 – PDE – Cytophaga hutchisonii
    
  • 2pz0 – PDE – Thermoanaerobacter tengcongensis
    
  • 2zo9, 2zoa – PDE + malonate – Enterobacter aerogenes
    
  • 3mz2, 3no3 – PDE – Parabacterioides distasonia
    
  • 4oec – PDE – Thermococcus kodakarensis
    
  • 5t9c, 5t9b – BsPDE + P3G
    
  • 5t91 – BsPDE + bicine
    
  • 7e0v – PfPDE – Pyrococcus furiosus
    
  • 7e2a – PfPDE (mutant)
    
  • 7e2b – PfPDE + palmitate + choline
    
  • 8cwp – PDE + glycerol – Haemophilus influenzae
    
• PDE
  • 5gz4 – TacPDE – Taiwan cobra
    
  • 5gz5 – TacPDE + AMP
    
  • 7cba – TacPDE + flavonoid
    
  • 2ahd – PDE – Methanocaldococcus jannaschii
    
  • 7bmf – MtPDE + CTP – Methanothermobacter thermautotrophicus”
    
  • 7bjq – MtPDE + DNA
    
  • 3qvq – PDE + P3G– Oleispira antarctica
    
  • 4b2o – BsPDE
    
  • 4g75, 4g76 – PaPDE
    
  • 5xsi – SaPDE catalytic domain
    
  • 5xt3 – SaPDE catalytic domain + C-di-GMP
    
  • 5xsn – SaPDE catalytic domain + C-di-AMP
    
  • 5xsp – SaPDE catalytic domain + AMP
    
  • 5vyd, 7d7p – SrPDE PDE domain 387-704 – Salpingoeca rosetta
    
  • 7cj3, 7d7q – SrPDE TM domain 33-378
    
  • 5o7f – TmPDE (mutant) + GMP
    
  • 5o1u – TmPDE + AMP
    
  • 5o70, 5o4z – TmPDE (mutant) + AMP
    
  • 5o58 – TmPDE (mutant) + RNA
    
  • 7dck – PDE tw9814 + RNA – Epsilonproteobacteria bacterium
    
  • 3s83 – CcPDEA EAL domain 289-547 – Caulobacter crescentus
    
  • 3u2e – CcPDEA EAL domain + pG-pG
    
  • 4hjf – CcPDEA EAL domain + C-di-GMP
    

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Michal Harel