Serine/threonine protein kinase 3D structures

3D structures of serine/threonine protein kinase

Updated on 19-August-2026

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• Chk1; domains - kinase 1-289; KA1 393-492
  • 1ia8 – hChk1 kinase domain – human
  • 5w12 – hChk1 KA1 domain
  • 1zlt – hChk1 kinase domain + hymenaldisine
  • 1nvq, 1nvr – hChk1 kinase domain + peptide + saurosporine
  • 1nvs, 1zys, 7ako - hChk1 kinase domain + peptide + inhibitor
  • 7akm - hChk1 kinase domain + ATP
  • 2ayp, 2br1, 2brb, 2brg, 2brh, 2brm, 2brn, 2bro, 2c3j, 2c3k, 2c3l, 2cgu, 2cgv, 2cgw, 2cgx, 2e9n, 2e9o, 2e9p, 2e9u, 2e9v, 2gdo, 2ghg, 2hog, 2hxl, 2hxq, 2hy0, 2qhm, 2qhn, 2r0u, 3f9n, 2wmq, 2wmr, 2wms, 2wmt, 2wmu, 2wmv, 2wmw, 2wmx, 2xey, 2xf0, 2xez, 2x8d, 2x8e, 2x8i, 2ydi, 2ydj, 2ydk, 2yer, 2yex, 2ym3, 2ym4, 2ym5, 2ym6, 2ym7, 2ym8, 2ywp, 3jvr, 3jvs, 3nlb, 3ot3, 3ot8, 3pa3, 3pa4, 3pa5, 3tkh, 3tki, 3u9n, 4fsm, 4fsn, 4fsq, 4fsr, 4fst, 4fsu, 4fsw, 4fsy, 4fsz, 4ft0, 4ft3, 4ft5, 4ft7, 4ft9, 4fta, 4ftc, 4fti, 4ftj, 4ftk, 4ftl, 4ftm, 4ftn, 4fto, 4ftq, 4ftr, 4ftt, 4ftu, 4gh2, 4hyh, 4hyi, 4jik, 4qye, 4qyf, 4qyg, 4qyh, 4rvk, 4rvl, 4rvm, 5dls, 5f4n, 5fcf, 5fck, 6fc8, 6fcf, 6fck, 7bko, 8e80, 8e81 - hChk1 kinase domain + inhibitor
    
  • 5oot, 5op2, 5op4, 5op5, 5op7, 5opb, 5opr, 5ops, 5opu, 5opv, 5oq5, 5oq6, 5oq7, 5oq8, 7bjd, 7bjh, 7bjj, 7bjm, 7bjo, 7bjr, 7bjx, 7bk1, 7bk2, 7bk3, 7mck, 7suf, 7sug, 7suh, 7sui, 7suj, 8siv, 8siw, 8six - hChk1 kinase domain (mutant) + inhibitor
  • 5oop - hChk1 kinase domain (mutant) + AMPPNP
  • 5oor - hChk1 kinase domain (mutant) + staurosporine
  • 7bkn - hChk1 kinase domain + adenine
  • 7bje - hChk1 kinase domain (mutant) + adenine
  • 2jqi – yChk1 – yeast
• Chk2 (Checkpoint kinase)
  • 1gxc – hChk2 phosphothreonine-binding domain + phosphopeptide
  • 2cn5 – hChk2 kinase domain + ADP
  • 2cn8 – hChk2 kinase domain + inhibitor
  • 2cn8, 2uv2, 2w0j, 2w7x, 2wtc, 2wtd, 2wti, 2wtj, 2xbj, 2xk9, 2xm8, 2xm9, 2ycf, 2ycq, 2ycr, 2ycs, 2yiq, 2yir, 2yit, 4a9r, 4a9s, 4a9t, 4bda, 4bdb, 4bdc, 4bdd, 4bde, 4bdf, 4bdg, 4bdh, 4bdi, 4bdj, 4bdk - hChk2 kinase domain + inhibitor
  • 3i6u, 3i6w – hChk2 residues 84-502 (mutant)
• Chk3 (Mst2); domains - kinase 13-313; SARAH 436-484
  • 3wws, 4hkd, 4l0n, 4oh9 – hChk3 SARAH domain
    
  • 4lg4 – hChk3 kinase domain
  • 4lgd – hChk3 kinase domain + RASSF5 SARAH domain
  • 6ao5 – hChk3 kinase+SARAH domains (mutant) + SAV1 SARAH domain
  • 5dh3, 8a66 – hChk3 kinase domain + inhibitor
• Chk4 (Mst1) ; Domains – kinase 1-311; SARAH 432-480
  • 3com – hChk4 kinase domain
  • 6yat, 8a5j– hChk4 kinase domain + inhibitor
  • 4nr2 – hChk4 SARAH domain
  • 2jo8 – hChk4 SARAH domain - NMR
  • 4oh8 – hChk4 SARAH domain + Ras association domain-containing protein
• Chk5 (Aurora kinase b)
  • 4af3 – hChk5 + inhibitor
• Chk6 or Chk15 or Aurora kinase A
  • 1mq4, 1muo, 4j8n, 4o0s, 6cpe – hChk6 kinase domain
    
  • 4bn1, 4o0w, 4o0u – hChk6 kinase domain (mutant)
  • 5dnr, 5drd, 5dt3 – hChk6 kinase domain + ATP
  • 5drd – hChk6 kinase domain + ATP
  • 1ol6 – hChk6 kinase domain (mutant) + ATP
  • 2wqe – hChk6 kinase domain (mutant) + ADP
  • 5odt – hChk6 kinase domain (mutant) + ADP + TACC3
  • 2c6d – hChk6 kinase domain (mutant) + ADPNP
  • 2dwb – hChk6 kinase domain + AMPPNP
  • 6cpf – hChk6 kinase domain + AMPPCP
  • 5g15 – hChk6 kinase domain + AMPPNP + monobody
  • 6cpg, 8ssp – hChk6 kinase domain + inhibitor + monobody
  • 2j4z, 2j50, 2np8, 2x81, 2x6d, 2x6e, 3efw, 3myg, 3vap, 3w10, 3w16, 3w18, 3w2c, 4b0g, 4byi, 4byj, 4j8m, 4jai, 4jaj, 4uyn, 4uzd, 4uzh, 4zs0, 4ztq, 4ztr, 4zts, 5aad, 5aae, 5aag, 5dpv, 5dr6, 5dr9, 5dt0, 5ew9, 5obr, 5one, 5zan, 6c2r, 6c2t, 6gra, 6z4y, 7ayh, 7ayi, 7fic, 7o2v, 8jmx – hChk6 kinase domain + inhibitor
    
  • 2bmc, 2c6e, 2wtw, 2xne, 2xng, 2xru, 3coh, 3fdn, 3h0y, 3h0z, 3h10, 3lau, 3k5u, 3m11, 3nrm, 3p9j, 3r21, 3r22, 3qbn, 3unz, 3uo4, 3uo5, 3uo6, 3uod, 3uoh, 3uoj, 3uok, 3uol, 3up2, 3up7, 4dea, 4deb, 4ded, 4dee, 4dhf, 4jbo, 4jbp, 4jbq, 4prj, 5aad, 5aae, 5aaf, 5aag, 5dpv, 6hjj, 6hjk – hChk6 kinase domain (mutant) + inhibitor
    
  • 5dt4, 5obj – hChk6 kinase domain + ATP + inhibitor
  • 5dos, 5dr2 – hChk6 kinase domain (mutant) + ATP + inhibitor
  • 5dn3, 5dos, 5dt4, 5obj – hChk6 kinase domain + ATP + inhibitor
  • 6c83 – hChk6 kinase domain + AMPPCP + nanobody
  • 8sso – hChk6 kinase domain + drug + monobody
  • 5dr2 – hChk6 kinase domain (mutant) + ATP + inhibitor
  • 5g1x, 7ztl – hChk6 kinase domain (mutant) + N-Myc
  • 8guw – hChk6 kinase domain/activator peptide
  • 5l8j, 5l8k, 5l8l – hChk6 kinase domain (mutant) + new antigen receptor variable domain
  • 5lxm – hChk6 kinase domain (mutant) + Targeting protein for XKLP2
  • 3daj, 3d14, 3dj5, 3dj6, 3dj7, 3d15, 3d2i, 3d2k – Chk6 kinase domain (mutant) + inhibitor - mouse
• Chk6 with phosphorylated Thr 287, Thr288
  • 1ol5, 1ol7 – hChk6 kinase domain + PThr + ADP
  • 5dnr, 5dt3 – hChk6 kinase domain + PThr + ATP
  • 2w1c, 2w1d, 2w1e, 2w1f, 2w1g, 5dn3 – hChk6 kinase domain + PThr + inhibitor
  • 2wtv, 5orl, 5orn, 5oro, 5orp, 5orr, 5ors, 5ort, 5orv, 5orw, 5orx, 5ory, 5orz, 5os0, 5os1, 5os2, 5os3, 5os4, 5os5, 5os6, 5osd, 5ose, 5osf – hChk6 kinase domain (mutant) + PThr + inhibitor
  • 3e5a, 3ha6 – hChk6 kinase domain + PThr + inhibitor + targeting protein for XKLP2
  • 5g1x – hChk6 kinase domain (mutant) + PThr + N-Myc
  • 5l8j, 5l8k, 5l8l – hChk6 kinase domain (mutant) + PThr + new antigen receptor variable domain
  • 5lxm – hChk6 kinase domain (mutant) + PThr + TPX2
  • 6r4d, 6r4c, 6r4b, 6r4a – hChk6 kinase domain + PThr + inhibitor + ADP
  • 6i2u – hChk6 kinase domain (mutant) + PThr + inhibitor + ADP
  • 6r49 – hChk6 kinase domain (mutant) + PThr + CoA
• Chk10 (lymphocyte-oriented kinase) or LOK or STK10
  • 7qgp – hChk10
  • 2j7t, 4aot, 4equ, 4usd, 4use, 5ajq, 5owq, 5owr, 6eim, 6gtt, 6i2y, 6hxf – hChk10 kinase domain + inhibitor
  • 4bc6, 6i2y – hChk10 + drug
• Chk11
  • 2wtk – hChk11 (mutant) + calcium-binding protein
• Chk12-A (Aurora kinase b-a or Aurora B kinase)
  • 2vgo, 2vgp, 2vrx, 3ztx, 4c2v, 5eyk – fChk12-A + inner centromere protein A peptide + inhibitor - frog
  • 4c2w – fChk12-A + inner centromere protein A peptide + AMPPNP
  • 4b8l, 4b8m, 5k3y – fChk12-A (mutant) + inner centromere protein A peptide + inhibitor
• Chk13 (Polo-like kinase Plk)
• Plk1 Polo-box domain (Pbd) 371-594
  • 1q4o, 2ogq, 3hih, 3p2w, 4h5x, 6n46 – hPlk1 Pbd
• Plk1 Pbd complex with polypeptide
  • 1umw, 2ojx, 3bzi, 3c5l, 3rq7, 4dfw, 4whl, 4whk, 4whh, 4rcp, 4o6w, 4o56, 5dms, 5dmv, 5dnj , 7mso, 7mx1 – hPlk1 + peptide
  • 3hik, 3fvh, 3p2z, 3p34, 3p35, 3p36, 3p37, 3q1i, 4e67, 4e9c, 4e9d, 4hab, 4hy2, 4o9w, 4x9r, 4x9v, 4x9w, 5j19, 6gy2 – hPlk1 + phosphopeptide
  • 1q4k – hPlk1 (mutant) + phosphopeptide
  • 2v5q – hPlk1 + design ankyrin repeat protein
  • 4lkl – hChk Plk1 + PL-55
  • 4lkm – hChk Plk1 + PL-74
  • 6ax4 – hChk Plk1 + histidine cyclized macrocycle
  • 5x3s – mPlk1 + phosphopeptide
  • 8joq, 8joy – hPlk1 Pbd + hpv peptide
• Plk1 Pbd complex with small molecule inhibitor
  • 4h71, 4hco, 5ta6, 5ta8, 8bjt, 8crc – hPlk1 + inhibitor
  • 2rku – hPlk1 (mutant) + inhibitor
  • 3db6, 3db8, 3dbc, 3dbd, 3dbe, 3dbf – zfPlk1 (mutant) + inhibitor – zebra fish
• Plk1 catalytic domain 36-345
  • 2owb – hPlk1 catalytic domain (mutant)
  • 2ou7 – hPlk1 catalytic domain (mutant) + AM
  • 3kb7, 2yac, 3thb, 4a4l, 4a4o – hPlk1 catalytic domain + inhibitor
  • 3fc2 – hPlk1 catalytic domain (mutant) + inhibitor
  • 4j52, 4j53 – hChk Plk1 (mutant) + inhibitor
  • 3d5x – zfPlk1 catalytic domain (mutant) + wortmannin
  • 3d5w – zfPlk1 catalytic domain + ADP
• Plk2
  • 4i5m, 4i5p, 4i6b, 4i6f, 4i6h – hChk Plk2 kinase domain (mutant) + inhibitor
  • 4xb0, 4rs6 – hChk Plk2 Pbd
• Plk3
  • 4b6l, 4i6b – hChk Plk3 kinase domain + inhibitor
• Plk4; Domains – kinase 2-275; Pbd 580-808; Pb3 884-970
  • 3cok – hChk Plk4 kinase domain
  • 4n9j – hChk Plk4 Pbd domain
  • 4n7z, 4n7v – hChk Plk4 Pbd domain + centrosomal protein
  • 6w38, 6w3i – hChk Plk4 Pbd domain + Fam46C
  • 6w3j – hChk Plk4 Pbd domain + Fam46C + CEP92 peptide
  • 4jxf, 4yur – hChk Plk4 kinase domain + inhibitor
  • 5lhy – hChk Plk4 Pb3 domain
  • 4yyp, 5lhz – hChk Plk4 Pb3 domain + Scl-interrupting locus protein
  • 4nk7, 4g7n, 5lhx, 7rl3 – DmChk Plk4 Pbd domain – Drosophila melanogaster
• Chk16
  • 2buj – hChk16 (mutant) + staurosporin
• Chk17B or DRAK2 or STK17B
  • 3lm0 – hChk17B
  • 6qf4, 7q7c, 7q7d – hChk17B + ADP
  • 7q7e – hChk17B + ATP
  • 3lm5 – hChk17B + quercetin
  • 6y6f, 6y6h, 6zjf – hChk17B + pyrimidine derivative
  • 7akg – hChk17B + drug
• Chk19 or STK19
  • 7xrb – hChk19
• Chk24 (Mst3) or STK24
  • 3a7f, 3a7g, 3a7h, 3a7i, 3a7j, 3ckw – hChk24 kinase domain
  • 4w8e, 4w8d, 4u8z, 4qmm, 4qmn, 4qmo, 4qmp, 4qmq, 4qms, 4qmt, 4qmu, 4qmv, 4qmw, 4qmx, 4qmy, 4qmz, 4qna, 4qo9, 4u8z, 7b30, 7b31, 7b32, 7b33, 7b34, 7b35, 8bzi, 8bzj, 8qlr, 8qls, 8qlt – hChk Mst3 + inhibitor
  • 8qlq – hChk Mst3 + macrocyclic inhibitor
  • 3ckx – hChk24 kinase domain + staurosporin
  • 3zhp – hChk24 kinase domain + calcium-binding protein
  • 4o27 – hChk24 kinase domain (mutant) + calcium-binding protein
  • 4qml – hChk Mst3 kinase domain + AMPPNP
• Chk25 or STK25
  • 2xik – hChk25 kinase domain
  • 7z4v – hChk25 kinase domain + inhibitor
  • 3w8h – hChk25 regulatory domain + programmed cell death protein 10
  • 4nzw – hChk25 kinase domain (mutant) + calcium-binding protein
• Chk26 (Mst4)
  • 3ggf, 7b36 – hChk Mst4 + inhibitor
  • 4geh, 3w8i - hChk Mst4 dimerization domain + programmed cell death protein 10
  • 4fza, 4fzd, 4fzf – hChk Mst4 (mutant) + calcium-binding protein
• Chk32
  • 4fr4 – hChk32A
• Chk38
  • 6bxi – hChk38 kinase domain
• Chk39 or SPAK
  • 7o86 – hChk39 C-terminal
  • 5d9h – mChk39 residues 63-403 + ATP
  • 5dbx – mChk39 residues 63-403 (mutant) + AMPPNP
• Chk40
  • 5l2q – hChk40 kinase homology domain
• Dclk1
  • 6kyq – hChk Dclk1 kinase domain
  • 6kyr – hChk Dclk1 kinase domain (mutant)
  • 5jzj – hChk Dclk1 kinase domain + AMPPN
  • 5jzn, 7kx6, 7kxw – hChk Dclk1 kinase domain + inhibitor
  • 7f3g – hChk Dclk1 kinase domain + drug
  • 7kx8 – hChk Dclk1 C-terminal + inhibitor
• Rac-α hChk (AKT1); domains: pleckstrin homology 1-123; kinase 144-480
  • 1unp, 1unr – hRac-α hChk pleckstrin homology domain
  • 2uzr, 2uzs, 7myx – hRac-α hChk pleckstrin homology domain (mutant)
  • 1h10, 1unq, 2uvm – hRac-α hChk pleckstrin homology domain + inositol tetrakisphosphate
  • 3o96, 4ejn, 6s9w, 6s9x, 6hhj, 6hhi, 6hhh, 6hhg, 6hhf - hRac-α hChk + inhibitor
  • 5kcv, 7nh4, 7nh5 - hRac-α hChk (mutant) + inhibitor
  • 4gv1, 4ekl - hRac-α hChk kinase domain + inhibitor
  • 3qkm, 6ccy - hRac-α hChk kinase domain (mutant) + inhibitor
  • 6buu - hRac-α hChk kinase domain + bisubstrate peptide
  • 4ekk - hRac-α hChk kinase domain (mutant) + GSK3 peptide + AMPPNP
  • 6npz - hRac-α hChk kinase domain + peptide + inhibitor
  • 3ow4, 3qkk, 3qkl, 6buu - hRac-α hChk kinase domain (mutant) + peptide + inhibitor
  • 7apj - hRac-α hChk + nanobody
• Rac-β hChk (AKT2)
  • 1gzk, 1gzn, 1gzo, 1mrv, 1mry – hRac-β hChk kinase domain
  • 1p6s - hRac-β hChk pleckstrin homology domain - NMR
  • 1o6k - hRac-β hChk kinase domain + GSK3 peptide + AMPPNP
  • 2jdo, 2jdr, 2uw9, 2x39, 3cqu, 3cqw - hRac-β hChk kinase domain + GSK3 peptide + inhibitor
  • 3e87, 3e88, 3e8d - Rac-β hChk kinase domain (mutant) + GSK3 peptide + inhibitor<br /
  • 1o6l - hRac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP
  • 3d0e, 8q61 - hRac-β hChk kinase domain (mutant) + inhibitor
• Rac-γ hChk (ATK3)
  • 2x18 – Rac-γ hChk PH domain
• A-Raf
  • 1wxm – hA-Raf RAS-binding domain 19-91 - NMR
  • 2mse – hA-Raf RAS-binding domain + APOA-I + K-ras - NMR
• B-Raf; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723
  • 8dgs, 8dgt – hB-Raf in Ras/Raf complex – Cryo EM
  • 7z37, 7z38, 7zr5 – hB-Raf + Hsp90 + CDC37 + PP5 – Cryo EM
  • 1uwh, 3c4c, 6v2u, 6xfp, 6xlo, 8f7o, 8f7p – hB-Raf kinase domain + anticancer drug
  • 1uwj, 6p3d – hB-Raf kinase domain (mutant) + anticancer drug
  • 2fb8, 3d4q, 3ii5, 3psd, 3skc, 3tv6, 4g9c, 4ksp, 4ksq, 3psb, 3ppj, 3ppk, 3prf, 3pri, 3tv4, 4dbn, 4e4x, 4mbj, 4ehe, 3q4c, 3q96, 3e26, 4h58, 4e26, 4fc0, 4pp7, 6cad, 7shv – hB-Raf kinase domain + pyrazole inhibitor
  • 4jvg, 4ehg, 4fk3, 3idp, 4g9r, 4wo5, 4mnf, 4r5y, 4rzv, 4rzw, 4xv1, 4xv2, 4xv3, 4xv9, 4yht, 5c9c, 5hi2, 5ita, 5jrq, 5jsm, 5jt2, 6nsq, 6p7d, 6uuo – hB-Raf kinase domain (mutant) + pyrazole inhibitor
  • 5csw, 5csx, 5ct7, 5fd2, 5hid, 5hie, 5val, 5vam, 6b8u, 6n0q, 6n0p, 7k0v, 7p3b, 7p3v, 8c7x, 8c7y - hB-Raf kinase domain + inhibitor
  • 6v34 – hB-Raf kinase domain (mutant) + inhibitor
  • 4mne – hB-Raf kinase domain + MAPKK1
  • 8f7o – hB-Raf kinase domain + drug
  • 7m0u – hB-Raf kinase domain + AMPPNP + drug
  • 6u2h – hB-Raf kinase domain + 14-3-3 ζ/δ
  • 7mfe – hB-Raf + 14-3-3 ζ/δ – Cryo EM
  • 7mff – hB-Raf + 14-3-3 ζ/δ + inhibitor – Cryo EM
  • 7mfd – hB-Raf + 14-3-3 ζ/δ + MEK + inhibitor – Cryo EM
  • 6pp9 – hB-Raf kinase domain + MEK1 + ANP
  • 7m0x, 7m0z – hB-Raf kinase domain + MEK1 + ANP + inhibitor
  • 7m0t, 7m0u, 7m0v, 7m0w, 7m0y – hB-Raf kinase domain + MEK1 + ANP + drug
  • 6u2g – hB-Raf kinase domain + MEK1 + AMPPCP
  • 5vr3 – hB-Raf BRS domain
  • 7jhp – hB-Raf BRS domain + Hras
  • 6ntc, 6ntd – hB-Raf BRS domain (mutant) + Hras
  • 6xi7 – hB-Raf 52-188 + Kras
  • 2l05, 5j17, 5j2r – hB-Raf RAS-binding domain - NMR
  • 3ny5 – hB-Raf RAS-binding domain
  • 5j18 – hB-Raf RAS-binding domain + inhibitor - NMR
  • 6pts, 6ptw – hB-Raf 56-187 + Kras + apolipoprotein + GMPPNP - NMR
  • 6uan, 6q0k – hB-Raf + 14-3-3 ζ – Cryo EM
  • 6nyb – hB-Raf + 14-3-3 ζ + MEK1 – Cryo EM
  • 6q0t, 6q0j – hB-Raf (mutant) + 14-3-3 ζ + MEK1 – Cryo EM
• c-Raf; Domains – RAS-binding (RBD) 55-132; Cys-rich 136-187 (CBD); kinase 323-618
  • 1rfa, 8jna, 8jof, 8jog – hc-Raf RBD - NMR
  • 1faq, 1far – hc-Raf cysteine-rich domain - NMR
  • 3omv – hc-Raf kinase domain
  • 1rrb – c-Raf RBD – NMR - rat
• c-Raf complex with protein
  • 8cpd – hc-Raf + 14-3-3 protein zeta – Cryo EM
  • 9mmp – hc-Raf + MEK1 + 14-3-3 protein zeta – Cryo EM
  • 9mmr – hc-Raf (mutant) + MEK1 + 14-3-3 protein zeta – Cryo EM
  • 1c1y – hc-Raf RBD + RAP1A
  • 3kuc – hc-Raf RBD (mutant) + RAP1A
  • 1gua – hc-Raf RBD + RAP1A + GPPNHP
  • 8jnb – hc-Raf RBD + ligand
  • 4g0n, 4g3x – hc-Raf RBD + GTPase Hras
  • 3kud – hc-Raf RBD (mutant) + GTPase Hras
  • 8epw, 8t74 – hc-Raf RBD + GTPase K-ras
  • 8t75, 9ygs – hc-Raf RBD-CRD + GTPase K-ras + GMPPNP
  • 9ay7, 9aya – hc-Raf + MEK1
  • 9mmq – hc-Raf + MEK1 – Cryo EM
  • 9mms – hc-Raf (mutant) + MEK1 – Cryo EM
  • 9o0u, 9o0v – hc-Raf (mutant) + MEK1 + ANP + inhibitor– Cryo EM
  • 8u1l – hc-Raf + Hsp90 + CDC37 – Cryo EM
  • 8gae, 8gft – hc-Raf + Hsp90 + CDC37 + PP5 – Cryo EM
• Snf1-related Chk
  • 3uc4, 3uc3, 3udb, 3zut, 3zuu – AtChk Srk2E kinase domain (mutant) – Arabidopsis thaliana
  • 3ujg – AtChk Srk2E kinase domain (mutant) + protein phosphatase 2C
  • 5yks – hChk
• MAPK-interacting Chk or Mnk1 Mnk2
  • 2hw6 – hMnk 1 catalytic domain
  • 2hw7 – hMnk 1 catalytic domain + staurosporin
  • 5wvd – hMnk 1 catalytic domain + inhibitor
  • 2ac3 – hMnk 2 catalytic domain
  • 2ac5 – hMnk 2 catalytic domain (mutant)
  • 6cj5, 6cje, 6cjh, 6cjw, 6cjy, 6ck3, 6ck6, 6cki – hMnk 2 catalytic domain (mutant) + inhibitor
• hChk Pak or Chk N or PRK1; Domains - CRIB 74-109; Hr1B 122-199; catalytic 109-426; kinase 605-942
  • 1urf – hChk Pak-1 Hr1b domain - NMR
  • 4nkg – hChk Pak-1 Hr1b domain + SSPH1 LRR domain
  • 2rmk – hChk Pak-1 Hr1bb domain + Rac1 - NMR
  • 1f3m – hChk Pak-1 autoregulatory+kinase domains
  • 4otd - hChk Pak-1 kinase domain
  • 1yhv, 1yhw, 3q4z, 3q52, 3q53 – hChk Pak-1 kinase domain (mutant)
  • 4o0r, 4o0t, 4zji, 4zjj, 4zlo, 4zy4, 4zy5, 4zy7, 5ime, 5kbq, 5kbr, 6b16, 7vto – hChk Pak-1 kinase domain + inhibitor
  • 4oti, 4oth, 4otg – hChk Pak-1 kinase domain + inhibitor
  • 4eqc, 4p90, 5dew, 5dey, 5dfp – hChk Pak-1 kinase domain (mutant) + inhibitor
  • 2hy8 – hChk Pak-1 kinase domain + staurosporin
  • 2qme – hChk Pak-1 CRIB domain + RAC3
  • 3fxz, 3fy0, 4daw – hChk Pak-1 kinase domain (mutant) + Ru complex
  • 6fd3 – hChk Pak-3 kinase domain (mutant)
  • 2j0i, 4fie – hChk Pak-4
  • 4fig, 4fij, 4l67 – hChk Pak-4 kinase domain
  • 2cdz – hChk Pak-4 + purine derivative
  • 2ov2 – hChk Pak-4 CRIB domain + RAC3
  • 2qon, 4fif, 4fih, 4fii, 4jdh, 4jdi, 4jdj, 4jdk, 6wlx, 6wly – hChk Pak-4 kinase domain + peptide
  • 4app, 4o0v, 4o0x, 4o0y, 4njd, 4xbu, 5bms, 5i0b, 5vee, 5vef, 5zjw, 5xvg, 5xvf, 5xva, 7cmb, 7cp3, 7cp4 – hChk Pak-4 kinase domain + inhibitor
  • 2x4z, 2xh5 – hChk Pak-4 kinase domain (mutant) + inhibitor
  • 5upl, 5upk – hChk Pak-4 kinase domain (mutant) + CDC42
  • 5ved – hChk Pak-4 kinase domain + staurosporine
  • 8ahi – hChk Pak-4 300-591 + inhibitor
  • 7s46, 7s48 – hChk Pak-4 catalytic domain + integrin beta-5 peptide
  • 2c30 – hChk Pak-6
  • 2odb – hChk Pak-6 CRIB domain + CDC42
  • 4ks8 – hChk Pak-6 kinase domain + sunitinib
  • 4ks7 – hChk Pak-6 kinase domain (mutant) + inhibitor
  • 2f57 – hChk Pak-7
• Mycobacterium tuberculosis Chk Pkn
  • 4x3f - MtChk PknA – Mycobacterium tuberculosis
  • 4ow8 - MtChk PknA kinase domain
  • 3ori, 3ork, 3orl, 3orm, 3oro, 3orp, 3ort - MtChk PknB kinase domain (mutant)
  • 1o6y – MtChk PknB kinase domain
  • 6b2p, 6b2q – MtChk PknB kinase domain + inhibitor
  • 2kud, 2kue, 2kuf, 2kui – MtChk PknB pasta domains 2-3 - NMR
  • 3ouv – MtChk PknB pasta domain 3
  • 5e0y – MtChk PknB pasta domain 4
  • 5e10 – MtChk PknB pasta domains 1-2
  • 5e0z – MtChk PknB pasta domains 3-4
  • 5e12 – MtChk PknB pasta domains 2-4
  • 5u94 - MtChk PknB kinase domain + inhibitor
  • 3f61, 3f69 - MtChk PknB kinase domain (mutant) + inhibitor
  • 6i2p - MtChk PknB kinase domain (mutant) + GARA + peptide
  • 1rwi, 1rwl - MtChk PknD extracellular domain
  • 2h34 – MtChk PknE catalytic domain
  • 7naa – MtChk PknF kinase domain + inhibitor
  • 4y12 - MtChk PknG + ATP-gS
  • 4y0x - MtChk PknG + ADP
  • 7q52 - MtChk PknG + inhibitor
  • 4esq - MtChk PknH extracellular domain
  • 5m06, 5xka - MtChk PknI kinase domain
  • 5m07, 5m08, 5m09 - MtChk PknI kinase domain (mutant)
  • 5xlm, 5xll - MtChk PknI sensor domain
  • 7mxb, 7mxj, 7mxk - Chk PknG kinase domain + AMPPNP - Corynebacterium glutamicum
• hChk Nek
  • 4apc – hChk Nek1 kinase domain (mutant)
  • 4b9d - hChk Nek1 kinase domain (mutant) + inhibitor
  • 2w5h – hChk Nek2 kinase domain
  • 2jav, 2wqo, 2xk3, 2xk4, 2xk6, 2xk7, 2xk8, 2xkc, 2xkd, 2xke, 2xkf, 2xnm, 2xnn, 2xno, 2xnp, 4a4x, 4afe, 5m51, 5m53, 5m55, 5m57, 6sgd, 6sgh, 6sgi, 6sgk, 6sk9 – hChk Nek2 + inhibitor
  • 2w5a, 2w5b – hChk Nek2 + nucleotide
  • 6tm5 - hChk Nek2 in anaphase-promoting complex – Cryo EM
  • 2wqm, 6s76 – hChk Nek7
  • 2wqn – hChk Nek7 + ADP
  • 5de2 – hChk Nek7 + hChk Nek9
  • 6s73, 2wqo – hChk Nek7 + inhibitor
  • 6npy – hChk Nek7 + Nlrp3
  • 6s75 – hChk Nek7 + inhibitor
• Chk Rio
  • 6fdo, 6fdn, 6fdm – hChk Rio2
  • 4otp – hChk Rio1 Rio domain + ADP
  • 6hk6, 7vbt – hChk Rio2 + inhibitor
  • 6eml, 6fai, 6g18, 6g51, 6rbd,6rbe, 6y7c – yChk Rio2 in 40S particle – Cryo EM
  • 1ztf – AfChk Rio1 + adenine derivative – Archaeoglobus fulgidus
  • 1zth – AfChk Rio1 + ADP
  • 1zp9 – AfChk Rio1 + ATP
  • 1tqp, 1zao – AfChk Rio2 + ATP
  • 1zar – AfChk Rio2 + ADP
  • 4gyg – CtChk Rio2 – Chaetonium thermophilum
  • 4gyi – CtChk Rio2 + ADP
• hChk Vrk (vaccinia-related kinase)
  • 2kty, 2kul, 2lav, 2rsv – hChk Vrk1 kinase domain 1-396 - NMR
  • 3op5 – hChk Vrk1 kinase domain (mutant)
  • 5ukf – hChk Vrk1 kinase domain + inhibitor
  • 5uvf, 6cnx, 6bu6, 6cfm, 6dd4, 6bp0, 6bru, 6btw, 6cmm, 6cqh, 6csw, 6npn, 6vxu, 6vzh – hChk Vrk1 kinase domain (mutant) + inhibitor
  • 6ac9 – hChk Vrk1 kinase domain (mutant) + AMPPNP
  • 7tan – hChk Vrk1 kinase domain + nucleosome – Cryo EM
  • 2v62 – hChk Vrk2 kinase domain
  • 5uu1, 6ncg, 8q1z – hChk Vrk2 kinase domain + inhibitor
• Chk Wnk (protein kinase lysine-deficient); Domains - kinase 194-483; CCT1 454-549
  • 6cn9, 4q2a, 4pwn - hChk Wnk1 kinase domain (mutant)
  • 5tf9 - hChk Wnk1 kinase domain + inhibitor + AMPPNP
  • 5wdy, 5we8 - hChk Wnk1 kinase domain + inhibitor + ANP
  • 5drb, 6ol2- rChk Wnk1 kinase domain (mutant) + inhibitor
  • 6elm - hChk Wnk2 CCT1 domain
  • 6fbk - hChk Wnk2 CCT1 domain + Wnk1 peptide
  • 5o1v, 5o21, 5o23 - hChk Wnk3 kinase domain
  • 5o2c - hChk Wnk3 kinase + CCT1 domains
  • 5o26, 5tf9 - hChk Wnk3 kinase domain + AMPPNP
  • 5o2b - hChk Wnk3 kinase domain + inhibitor
  • 8edh - hChk Wnk3 kinase domain (mutant) + inhibitor
  • 2lru – rChk Wnk1 autoinhibitory domain 480-572 - NMR
  • 5w7t - rChk Wnk1 kinase domain
  • 7uos - rChk Wnk1 kinase domain (mutant)
• TANK-binding kinase
  • 4efo – hChk Tbk1 ubiquitin-like domain
  • 6rsr, 6rsu – hChk Tbk1 + inhibitor
  • 4im0, 4im2, 4im3, 4iw0, 4iwo, 4iwp, 4ipq, 6rst – hChk Tbk1 (mutant) + inhibitor
  • 6cq5, 6cq4, 6cq0, 6boe, 6bod, 6bny, 5w5v – hChk Tbk1 + ulcer drug
  • 4eut, 4euu – hChk Tbk1 kinase+ubiquitin-like domains (mutant) + inhibitor
  • 6nt9 – hChk Tbk1 (mutant) + STING
  • 5eoa, 5eof – hChk Tbk1 residues 677-729 + optineurin
  • 4jl9, 4jlc – mChk Tbk1 + inhibitor
  • 6o8c, 6o8b – mChk Tbk1 (mutant) + STING
• Haspin
  • 2vuw, 2wb8 – hChk Haspin kinase domain
  • 3dle – hChk Haspin kinase domain + AMP
  • 3e7v, 3f2n, 3fmd, 3iq7, 4qtc, 5htb, 5htc, 6z56, 6z57, 6z58, 6z59, 6z5a, 6z5b, 6z5c. 6z5d, 6z5e , 7avq, 7ops – hChk Haspin kinase domain + inhibitor
  • 7sqm – hChk Haspin kinase domain + antimalarial
  • 6g38, 6g34, 6g35, 6g36, 6g37 – hChk Haspin kinase domain + tubercidin derivative
  • 6g39, 6g3a – hChk Haspin kinase domain (mutant) + tubercidin derivative
  • 4ouc – hChk Haspin kinase domain + histone H3 peptide
• MAP/microtubule affinity-regulating kinase (MARK)
  • 2hak – hChk MARK1 catalytic+UBA domains
  • 3ose - hChk MARK1 KA1 domain
  • 6c9d – hChk MARK1 catalytic+UBA+KA1 domains (mutant)
  • 5eak, 5kz7, 5kz8 – hChk MARK2 catalytic+UBA domains + inhibitor
  • 3iec – hChk MARK2 catalytic+UBA domains + cytotoxicity-associated immunodominant antigen peptide
  • 2qnj – hChk MARK3 catalytic+UBA domains
  • 3fe3 – hChk MARK3 catalytic+UBA domains (mutant)
  • 7p1l – hChk MARK3 catalytic+UBA domains + inhibitor
  • 5es1 – hChk MARK4 catalytic+UBA domains + inhibitor
  • 1zmu – rChk MARK2 catalytic+UBA domains
  • 2wzj, 2r0i, 1zmv, 1y8g, 1zmw – rChk MARK2 catalytic+UBA domains (mutant)
  • 1ul7, 1v5s - mChk MARK3 catalytic domain - NMR
• Mitotic checkpoint Chk (Bub); Domains: TPR 1-220; kinase 726-1085
  • 2lah – hChk Bub1 TPR domain – NMR
  • 2wvi – hChk Bub1β TPR domain
  • 3si5 – hChk Bub1 TPR domain + CASC5 peptide
  • 4r8q, 4qpm, 5dmz – hChk Bub1 kinase domain + ADP
  • 6f7b – hChk Bub1 kinase domain + inhibitor
  • 4a1g – hChk Bub1 TPR domain + CASC5 KI motif
  • 4ggd - hChk Bub1 + cell division cycle protein
  • 6tlj, 5khu - hChk Bub1 in anaphase-promoting complex – Cryo EM
  • 6jkk – DmChk Bub1 kinase domain
  • 6jkm – DmChk Bub1 kinase domain + ADP
  • 5jja – hChk Bub1 residues 661-734 + PP2A
  • 3esl – yChk Bub1 N terminal
  • 4bl0 - yChk Bub1 + cell cycle arrest protein Bub3
• Microtubule-associated Chk
  • 2m9x – hChk 1 residues 187-287 – NMR
  • 3ps4 - hChk 1 residues 965-1057
  • 2kqf, 2kyl – hChk 2 PDZ domain + glycoprotein C terminal – NMR
  • 3khf - hChk 3 PDZ domain
  • 2w7r – hChk 4 PDZ domain
• mTOR or Mechanistic target of rapamycin
• mTOR FRB domain residues 2015-2114
  • 1nsg, 1fap – hFRAP FRB domain + FKBP
  • 2rse – hFRAP FRB domain + FKBP – NMR
  • 1aue – hFRAP FRB domain
  • 2gaq, 2npu – hFRAP FRB domain - NMR
  • 8ppz – hFRAP FRB domain + FKBP + pyridine derivative
  • 3fap, 2fap, 4fap – hFRAP FRB domain + FKBP + rapamycin analog
  • 4drh, 4dri, 4drj, 5gpg – hFRAP FRB domain + FKBP + rapamycin
  • 6m4u, 6m4w – hChk Mtor FRB domain (mutant) + FKBP1A + rapamycin
  • 5wbh – hFRAP FRB domain + S6K1 peptide
• mTOR FAT+PIKK domain residues 1376-2549
  • 4jsn – hFRAP + TORC subunit LST8
  • 4jsp – hFRAP + TORC subunit LST8 + ATP
  • 4jsv – hFRAP + TORC subunit LST8 + ADP
  • 4jsx – hFRAP + TORC subunit LST8 + torin2
  • 4jt5 – hFRAP + TORC subunit LST8 + pp242
  • 4jt6 – hFRAP + TORC subunit LST8 + PI-103
  • 5wby, 5wbu – hFRAP + TORC subunit LST8 + proline-rich Akt1 substrate
• mTOR complex
  • 5flc – hmTOR + RAPTOR + LST8 + FKBP – Cryo EM
  • 5h64 – hmTOR + RAPTOR + LST8 – Cryo EM
  • 6sb2 – hChk Mtor + RAPTOR + LST8 + RAGA + RAGC – Cryo EM
  • 6sb0 – hChk Mtor + RAPTOR + LST8 + RAGA + RAGC + proline-rich Akt1 substrate – Cryo EM
  • 5zcs – hmTOR + LST8 + AVO3 + TORC2 – Cryo EM
  • 7tzo – hTORC2 in mTORC2 complex– Cryo EM
  • 6zwm, 6zwo, 7owg, 7pe7, 7pe8, 7pe9, 7pea, 7peb, 7pec, 7uxc , 8era– mTOR in mTor complex – Cryo EM
• Gcn2
  • 1zyc – yChk Gcn2
  • 1zxe, 1zy4, 1zy5 – yChk Gcn2 (mutant)
  • 2yz0 – yChk Gcn2 RWD/GI domain – NMR
  • 4otm – yChk Gcn2 C terminal domain
  • 1zyd – yChk Gcn2 + ATP
  • 4otn – mChk Gcn2 C terminal domain
• LRRK1 or leucine-rich repeat Chk1
  • 8e04, 8e05, 8e06, 8fac – hLRRK1 – Cryo EM
• LRRK2 or leucine-rich repeat Chk2 or dardarin
  • 6xr4 – hLRRK2 – Cryo EM
  • 7lht, 7lhw, 7li4 – hLRRK2 + ATP + GDP – Cryo EM
  • 7li3 – hLRRK2 (mutant) + ATP + GDP – Cryo EM
  • 6oje, 7thy – hLRRK2 GTPase domain 1329-1520
  • 6ojf – hLRRK2 GTPase domain (mutant)
  • 6dlo, 6dlp – hLRRK2 WD40 domain
  • 7thz – hLRRK2 1330-1527 + GDP
  • 6vno, 6vp6, 6vp7 – hLRRK2 C terminal 1330-2527 – Cryo EM
  • 6vp8 – hLRRK2 C terminal 1330-2527 + COR domain 1670-1950 + WD40 domain 2140-2489 – Cryo EM
  • 6s6q – AtLRRK2 ectodomain + protein casparian strip peptide
• Pim
• Pim1 catalytic domain residues 14-313
  • 1xqz, 1ywv, 4jx3 – hPim1 catalytic domain
  • 1yxs – hPim1 catalytic domain (mutant)
  • 1xr1, 1yxt – hPim1 catalytic domain + AMPPNP
  • 1yxu – hPim1 catalytic domain + AMP
  • 1yxv, 5ipj – hPim1 catalytic domain + quinoline derivative
  • 1yxx – hPim1 catalytic domain + indole derivative
  • 2bzh, 2bzi, 2bzj – hPim1 catalytic domain (mutant) + organometallic ligand
  • 2o3p, 2o63, 2o64, 2o65, 3c4e, 3jxw, 3jy0, 3jya, 3r00, 3r01, 3r02, 3r04, 3vbq, 3vbt, 3vbv, 3vbw, 3vbx, 3vby, 3vc4, 3umw, 3umx, 4enx, 4eny, 4k1b, 4k18, 4k0y, 4iaa, 4i41, 4ll5, 4lm5, 4lmu, 4mta, 4med, 4mbl, 4mbi, 4n6y, 4n6z, 4n70, 4xh6, 5iis, 5kgd, 5kge, 5kgg, 5kgi, 5kgk, 5kzi, 5vua, 5vub, 5vuc, 6mt0, 6vrv, 7oov, 7oow, 7oox, 7xsv – hPim1 catalytic domain + inhibitor
  • 2j2i, 3we8 – hPim1 catalytic domain (mutant)+ inhibitor
• Pim1 kinase domain residues 92-404
  • 4jx3 – hPim1 kinase domain
  • 3uix, 5c1q – hPim1 kinase domain residues 120-404 + quinoline derivative
  • 3a99 – hPim1 kinase domain + phosphoaminophosphonic acid adenylate
  • 2oi4, 3bwf – hPim1 kinase domain (mutant) + organometallic ligand
  • 1xws, 4alu, 4alv, 4alw, 4as0, 4bzn, 4bzo, 4dtk, 4jx7, 4rbl, 4rc2, 4rc3, 4rc4, 4ty1, 4wrs, 4wsy, 4wt6, 4xhk, 5dgz, 5dhj, 5dia, 5dwr, 5eol, 5kcx, 5o11, 5o12, 5o13, 5tel, 5tex, 5toe, 5v80, 5v82. 6bsk, 6kzi, 6l11, 6l12, 6l13, 6l14, 6l15, 6l16, 6l17, 6no8, 6no9, 6vru, 6ykd, 7zun – hPim1 kinase domain + inhibitor
  • 6ayd – hPim1 kinase domain (mutant)+ inhibitor
• Pim1 full length
  • 4rpv, 5tur - hPim1 + inhibitor
• Pim1 complex with consensus peptide (pimtide)
  • 2bil, 3cxw, 3cy2, 3cy3, 6qxk, 6pcw, 6pdi, 6pdn, 6pdo, 6pdp – hPim1 kinase domain + inhibitor + consensus peptide
  • 3jpv, 3qf9 - hPim1 catalytic domain + inhibitor + consensus peptide
  • 2c3i, 5ndt, 5n5m, 5n5l, 5n52, 5n51, 5n50, 5n4z, 5n4y, 5n4x, 5n4v, 5n4u, 5n4r, 5n4o, 5n4n, 5mzl – hPim1 kinase domain (mutant) + inhibitor + consensus peptide
  • 4gw8, 7qb2, 7qfm, 7z6u, 8afr – hPim1 catalytic domain (mutant) + inhibitor + pimtide
  • 2bzk – hPim1 kinase domain (mutant)+ AMPPNP + consensus peptide
  • 3ma3 – hPim1 catalytic domain + inhibitor + PSer + consensus peptide
• Pim1 containing phosphorylated Ser 261
  • 1yhs – hPim1 kinase domain + PSer + staurosporine
  • 1yi3, 2bik, 2xix, 2xiy, 2xiz, 2xj0, 2xj1, 2xj2, 4a7c – hPim1 kinase domain + PSer + inhibitor
  • 2obj, 3bgp, 3bgq, 3bgz, 3dcv, 3f2a, 3t9i - hPim1 catalytic domain + PSer + inhibitor
  • 1yi4 – hPim1 kinase domain + PSer + adenosine
• Pim2
  • 4x7q – hPim2 catalytic domain + inhibitor
  • 2iwi – hPim2 catalytic domain + Ru ligand
• Rip or receptor-interacting Chk; Domains – catalytic 1-294; Amyloid fibril 418-518; Death 561-671
  • 6ac5 – hRip1 death domain
  • 6r5f, 6nw2, 6c4d, 6c3e, 5tx5, 7fcz, 7fd0, 7ydx – hRip1 catalytic domain + inhibitor
  • 6rln, 6ocq, 6nyh, 6hho – hRip1 catalytic domain (mutant) + inhibitor
  • 6ggs – hRip2 – Cryo EM
  • 5yrn – hRip2 CARD domain 434-540 – Cryo EM
  • 6szj, 6sze, 6s1f, 6rna, 6rn8, 6hmx, 6fu5, 6es0, 5w5o, 5w5j – hRip2 catalytic domain + inhibitor
  • 6ul8 – hRip2 catalytic domain (mutant) + inhibitor
  • 8aza – hRip2 catalytic domain + XiaP Bir2 domain – Cryo EM
  • 7mx3 – hRip3 catalytic domain (mutant) + inhibitor
  • 7mon – hRip3 catalytic domain (mutant) + MLKL
  • 7dac – hRip3 amyloid fibril - NMR
  • 7da4 – hRip3 amyloid fibril – Cryo EM
  • 6oko – mRip3 catalytic domain + inhibitor
  • 6jpd – mRip3 residues 409-486 - NMR
  • 5wnm, 5wnj – mRip4 catalytic domain (mutant) + drug
  • 5wnl – mRip4 catalytic domain (mutant) + staurosporine
  • 5wnk – mRip4 catalytic domain (mutant) + inhibitor
  • 5wni – mRip4 catalytic domain (mutant) + ATP
  • 6gwm – rRip2 caspase recruitment domain 433-539
• Ulk
  • 6qas – hChk Ulk1 + inhibitor
  • 5ci7, 6mnh – hChk Ulk1 (mutant) + inhibitor
  • 4wnp, 4wno – hChk Ulk1 + IST1 homolog
  • 8soi, 8sqz – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein
  • 8srm – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein – Cryo EM
  • 8srq – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein + PI3K – Cryo EM
  • 6qav, 6qau, 6qat, 6yid – hChk Ulk2 + inhibitor
  • 4wzx – hChk Ulk3 MIT 2 domain + inhibitor
  • 6fdz, 6fdy – hChk Ulk3 + leukemia drug
  • 6tsz – hChk Ulk4 pseudfokinase domain + ATPgS
  • 6u5l – hChk Ulk4 (mutant) + inhibitor
• Hipa and Hipb
  • 3tpd, 3tpe – EcChk Hipa – Escherichia coli
  • 3tpb, 3dnt, 3dnu – EcChk Hipa (mutant)
  • 4pu7, 4pu8 – SoChk Hipb - Shewanella oneidensis
  • 3tpt – EcChk Hipa (mutant) + ADP
  • 3fbr – EcChk Hipa (mutant) + AMPPNP + peptide
  • 3tpv – EcChk Hipa + ADP
  • 2wiu – EcChk Hipa + Hipb
  • 4yg7, 5k98, 3hzi, 3dnv – EcChk Hipa + Hipb + DNA
  • 4yg1, 4z58, 4z59, 4z5c, 4z5d – EcChk Hipb + DNA
  • 4z5h – EcChk Hipb (mutant) + DNA
  • 4pu3, 4pu4 – SoChk Hipa + Hipb + DNA - Shewanella oneidensis
  • 4pu5 – SoChk Hipa + AMPPNP
• Chk Smg
  • 6l53 – hChk Smg1 – Cryo EM
  • 7pw6 – hChk Smg1 + inhibitor – Cryo EM
  • 7pw7 – hChk Smg1 + Smg9 + inhibitor – Cryo EM
  • 7pw9 – hChk Smg1 + Smg9 + AMPPNP + ATP – Cryo EM
  • 6l54, 6syt – hChk Smg1 + Smg8 + Smg9 – Cryo EM
  • 7pw4, 7pw5 – hChk Smg1 + Smg8 + Smg9 + inhibitor – Cryo EM
  • 7pw8 – hChk Smg1 + Smg8 + Smg9 + AMPPNP – Cryo EM
  • 6z3r – hChk Smg1 + Smg8 + Smg9 + regulator of nonsense transcripts – Cryo EM
  • 2hwy – hChk Smg5 PIN domain
  • 2hww, 2hwx – hChk Smg6 PIN domain (mutant)
  • 4um2 – hChk Smg6 TPR domain
  • 1ya0 – hChk Smg7 N terminal
• Chk Vprbp or DCAF1
  • 4pxw, 8ood – hChk Vprbp WD repeat domain 1039-1401 (mutant)
  • 7sse, 7ufv, 8f8e, 8og5, 8og6, 8og7, 8og8, 8og9, 8oga, 8ogb, 8ogc, 8oo5, 8ood – hChk Vprbp WD repeat domain (mutant) + inhibitor
  • 7v7c – hChk Vprbp in DDB1-VPRBP-VPR-UNG2 complex – Cryo EM
  • 5aja – hChk Vprbp WD repeat domain + VPX + SAMHD1
• Other Chk
  • 1wak – hChk Sprk1
  • 3dak – hChk Osr1 kinase domain
  • 7okw – hChk Osr1 C-terminal
  • 4aw2 – hChk Mrckα kinase domain
  • 4pxw, 8ood – hChk Vprbp WD repeat domain (mutant)
  • 7v7c – hChk Vprbp in DDB1-VPRBP-VPR-UNG2 complex – Cryo EM
  • 1uf0 – hChk Dcamkl1 DCX domain – NMR
  • 1u5q – rChk Tao2 kinase domain
  • 2cos – mChk Lats2 – NMR
  • 1xte, 1xtn, 6edx – mChk Sgk3 PX domain
  • 4yom – mChk Brsk2
  • 4ynz – mChk Brsk1 N terminal domain
  • 5iri – mChk Brsk1 residues 592-719
  • 5oat, 7mp8 – rfbChk Pink1– red flour beetle
  • 7t3x – Chk Pink1 (mutant) – louse
  • 4f0g – smChk Roco4 kinase domain – slime mold
  • 5tos – AtChk Bik1
  • 1q8z, 1zyc – yChk
  • 1how, 1zxe, 1zy4 – yChk (mutant)
  • 1ow5, 1x9x – yChk Ste11 SAM domain – NMR
  • 2kio, 2kit, 1w1n – yChk Tor1 FATC domain – NMR
  • 3gre – yChk Vps15 WD repeat domain
  • 3osm, 3ost - yChk Kcc4 kinase domain
  • 5yyx – yChk Mek1 FHA domain
  • 6jxc, 6jxa – yChk Tel1 – Cryo EM
  • 6u69 – CaChk Yck2 – Candida albicans
  • 6sl1, 6sl0, 6skz, 6sky – Chk Tel1 – Chaetonium thermophilum – Cryo EM
  • 6ra0 – CeChk Dkf1 – Chaenorhabditis elegans
  • 7z6e – CeChk Mrck1 regulatory domain
  • 6tlb – Chk – Plasmodium falciparum
• Other Chk complexes
  • 1wbp, 7dd1 – hChk Sprk1 + peptide
  • 3beg – hChk Srpk1 + splicing factor SF2
  • 3hdm, 3hdn, 7pue – hChk Sgk1 (mutant) + inhibitor
  • 2r5t – hChk Sgk3 + AMPPNP
  • 4yff, 4yfi, 6b5j, 7mgj, 7mgk – hChk Tnni3k + inhibitor
  • 2v3s – hChk Osr1 + hChk Wnk4 peptide
  • 2vwi – hChk Osr1 kinase domain + ANP
  • 7que, 7quf – hChk Drak1 kinase domain + inhibitor
  • 4crs – hChk N2 kinase domain + ATPγS
  • 3tku, 4ual, 3qfv, 5ote, 5otf – hChk Mrckβ + inhibitor
  • 4uak – hChk Mrckβ + ADP
  • 5aja, 4z8l, 4cc9 – hChk Vprbp WD repeat domain + VPX + SAMHD1
  • 5jk7 – hChk Vprbp WD repeat domain + VPX + DDB1 + UDG
  • 3wa0, 4p7i – hChk Vprbp residues 1417-1506 + merlin
  • 4wzx – hChk Ulk3 MIT 2 domain + inhibitor
  • 5ci7 – hChk Ulk1 (mutant) + inhibitor
  • 4wnp, 4wno – hChk Ulk1 + IST1 homolog
  • 5b5w, 5b6b, 5brk – hChk Lats1 residues 622-704 + MOB1
  • 5yz0 – hChk Atr + Atr-interacting protein – Cryo EM
  • 6bdn – hChk Tao3 kinase domain + ADP
  • 5yh3 – hChk Fam20C 141-578 + pseudokinase Fam20A
  • 2gcd – rChk Tao2 kinase domain + staurosporine
  • 1u5r – rChk Tao2 kinase domain + ATP
  • 5yj9, 7mp9 – rfbChk Pink1 kinase domain + AMPPNP
  • 6bn1 – DmChk Hippo SARAH domain + Shar-Pei
  • 3hgk – Chk Pto + effector protein AVRPTOB – Currant tomato
  • 3p86, 3ppz - AtChk Ctr1 + staurosporine
  • 4f0f – smChk Roco4 kinase domain + APPCP
  • 4f1m, 4f1o – smChk Roco4 kinase domain (mutant) + APPCP
  • 4f1t, 4yzm, 4yzn – smChk Roco4 kinase domain + inhibitor
  • 5fvm - Tor2 + LST8 - Kluyveromyces marxianus
  • 5kc2 - yVps15 + Vps34 - Cryo EM
  • 5dfz - yVps15 + Vps34 + Vps30 + VPSAP28 + VPSAP30 - Cryo EM
  • 1q8y, 1q97, 1q99, 1zyd – yChk + nucleotide
  • 1zy5 – yChk (mutant) + nucleotide
  • 2jd5 – yChk + NPL-3P
  • 4lqs, 4lqq, 4lqp – yChk Cbk1 residues 251-756 + Cbk1 activator Mob2
  • 6emk – yChk Tor2 + LST8 + TSC11 + AVO1 + AVO2 – Cryo EM
  • 6s8f – yChk Tel1 + AMPPNP – Cryo EM
  • 5yyz – yChk Mek1 FHA domain + Hop1
  • 5x6o, 6z3a, 7wzr, 7wzw– yChk Mec1 + LCD1 – Cryo EM
  • 6z2w, 6z2x – yChk Mec1 (mutant) + LCD1 – Cryo EM
  • 7kue – yChk Kin28 in TFIIK complex – Cryo EM
  • 6u6a – CaChk Yck2 + inhibitor
  • 5fvm – Chk Tor2 + LST8 – Kluyveromyces maximanus
• Serine/threonine protein kinase Rad53 see Rad53
• Serine/threonine protein kinase Gsk3B see Glycogen synthase kinase 3

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Michal Harel, Joel L. Sussman, Openfox, Jaime Prilusky