From Proteopedia

Jump to: navigation, search

The ConSurf Server, a project led by Nir Ben-Tal and Tal Pupko (Tel-Aviv University, Israel), colors each amino acid in a protein structure by its level of evolutionary conservation. Functional sites are marked by clusters of conserved surface residues. Available since 2002 and constantly upgraded, all methods are documented and its algorithms are published in peer-reviewed journals. When the confidence interval around a conservation grade is too wide, ConSurf assigns that residue a yellow color for "insufficient data".

For some quick examples, see Introduction to Evolutionary Conservation.

Below are listed pages in Proteopedia about evolutionary conservation, how to use the ConSurf Server, and how to interpret its results to identify functional sites in proteins.


  • Introduction to Evolutionary Conservation: an explanation starting at the beginning, with examples.
  • Conservation, Evolutionary covers
    • How to locate conserved and variable patches
    • Conservation expected to support folding of domains
    • Unrelated sequences in the MSA obscure functional sites, re: ConSurfDB
    • Comparing sequence-different chains
    • Drift in results over time due to database growth
    • Other evolutionary conservation servers besides ConSurf


See Also

Proteopedia Page Contributors and Editors (what is this?)

Eric Martz

Personal tools