RNA polymerase 3D structures

3D Structures of RNA polymerase

Updated on 06-May-2020

{"openlevels":0}

• Prokaryotic DNA-dependent RNAP
  • 2y0s – SsRNAP – Sulfolobus shibata
    
  • 1ryq - PfRNAP subunit ε - Pyrococcus furiosus
    
  • 1go3 – MjRNAP subunit RPB4, RPB7 - Methanocaldococcus jannaschii
    
  • 1iw7, 1smy, 6asg - TtRNAP subunits α,β,β',ω Thermus thermophilus
    
  • 1doq - TtRNAP subunit α
    
  • 3lti– EcRNAP subunit β fragment – Escherichia coli
    
  • 4iqz - EcRNAP subunit β’
    
  • 3k4g, 1coo - EcRNAP subunit 
    
  • 1bdf - EcRNAP subunit α mutant)
    
  • 3lu0 - EcRNAP subunits α,β,β',ω – Electron diffraction
    
  • 2krc - BsRNAP subunit δ N-terminal – Bacillus subtilis – NMR
    
  • 2ly7 - BsRNAP subunit β NMR
    
  • 2m4k - BsRNAP subunit δ NMR
    
  • 4nc7, 4nc8 - BsRNAP subunit δ
    
  • 2max - HpRNAP subunit α - Helicobacter pylori - NMR
    
  • 1qyp – RNAP II C terminal – Thermococcus celer – NMR
    
  • 4kbj – MtuRNAP β subunit – Mycobacterium tuberculosis
    
  • 5uh7 - MtuRNAP subunit ’
    
  • 4noi – RNAP α subunit – Campylobacter jejuni
    
  • 1hqm – TaRNAP subunits α,β,β',ω Thermus aquaticus
    
  • 2gho - TaRNAP subunits α,β,β'
    
  • 2auj, 2auk - TaRNAP subunit β’
    
  • 1xpp – RNAP subunit L – Thermoplasma acidophilum
    
  • 2waq, 2wb1, 4ayb – SsRNAP
    
  • 3e7h – VcRNAP subunit – Vibrio cholera
    
  • 1ef4 – MtRNAP subunit RPB10 – Methanothermobacter thermautotrophicus
    
  • 1eik - MtRNAP subunit RPB5 – NMR
    
  • 4qiw – TkRNAP subunits a’’+d+e’+f+h+k+l+n+p – Thermococcus kodakarensis
    
  • 4qjf - TkRNAP subunits e’+f
    
  • 4qjv - TkRNAP subunits d+l
    
  • 6eyd, 6f6w – MsRNAP subunits α,β,β',ω - Mycobacterium smegmatis – Cryo EM
    
• Prokaryotic DNA-dependent RNAP complex with DNA/RNA
  • 4v8s – SsRNAP + DNA
    
  • 3q22, 3q23, 3q24, 4ff1, 4ff2, 4ff3, 4ff4 – RNAP + DNA – Enterobacteria phage N4
    
  • 2o5i, 2o5j, 4gzy, 4gzz, 4xln, 4xlr - TtRNAP subunits α,β,β',ω + DNA +RNA
    
  • 5x22 - TtRNAP subunits α,β,β',ω + DNA + RNA + CMPCPP
    
  • 5x21 - TtRNAP subunits α,β,β',ω + DNA + RNA + antibiotic
    
  • 4wqs, 4xlp, 4xlq, 4xls, 5tjg - TtRNAP subunits α,β,β',ω + DNA
    
  • 2ppb - TtRNAP subunits α,β,β',ω + antibiotic + DNA + RNA + substrate analog
    
  • 4yg2, 4jk1, 4jk2, 4jkr, 4kmu - EcRNAP subunits α,β,β',ω RNA
    
  • 6flp, 6bjs, 6asx, 6alh, 6alf, 6rip, 6ri9 - EcRNAP subunits α,β,β',ω RNA + DNA – Cryo EM
    
  • 6rh3 - EcRNAP subunits α,β,β',ω RNA + DNA + GMP + CTP – Cryo EM
    
  • 4kn4, 4kn7 - EcRNAP subunits α,β,β',ω RNA + antibiotic
    
• Prokaryotic DNA-dependent RNAP complex with protein
  • 3p8b – PfRNAP subunit ε’’ + transcription antitermination protein
    
  • 3qqc - PfRNAP subunits β, ε’’ + transcription antitermination protein
    
  • 2be5- TtRNAP subunits α,β,β’,ω + σ factor + inhibitor
    
  • 2cw0, 5tmf - TtRNAP subunits α,β,β’,ω + σ factor
    
  • 3wod - TtRNAP subunits α,β,β’,ω + σ factor + GP39
    
  • 4mq9 - TtRNAP subunits α,β,β’,ω + σ factor + GE23077
    
  • 5tmc - TtRNAP subunits α,β,β’,ω + σ factor + protein
    
  • 3dxj, 3eql - TtRNAP subunits α,β,β’,ω + σ factor + antibiotic
    
  • 5xj0 - TtRNAP subunits α,β,β’,ω + σ factor + GP39 + GP76
    
  • 4wqt - TtRNAP subunits α,β,β’,ω + RNA cleavage stimulating factor
    
  • 3mlq - TtRNAP subunit β + transcription-repair coupling factor
    
  • 3woe, 3wof - TtRNAP subunit β + GP39
    
  • 2lmc - EcRNAP subunit β + RNAP inhibitor
    
  • 3mmp - EcRNAP subunit β + EF-TU
    
  • 4ljz, 4lk1, 4mey, 4xsx, 4xsy, 4xsz, 4zh2, 4zh3 , 4zh4, 5byh, 5nwt, 5uag, 5uah, 5uaj, 5ual, 5uaq, 5ui8 - EcRNAP subunits α,β,β’,ω + σ factor
    
  • 6c9y - EcRNAP subunits α,β,β’,ω + σ factor – Cryo EM
    
  • 4mex - EcRNAP subunits α,β,β’,ω + σ factor + salinamide
    
  • 4lk0, 4llg, 4mex, 4yfk, 4yfn, 4yfx - EcRNAP subunits α,β,β’,ω + σ factor + RNAP inhibitor
    
  • 5uac, 6cux - EcRNAP subunits α,β,β’,ω + σ factor + antibiotic
    
  • 6byu - EcRNAP subunits α,β,β’,ω + σ factor + PPAPP
    
  • 5w1s - EcRNAP subunits α,β,β’,ω + σ factor + TRAR
    
  • 6rin, 6ri7 - EcRNAP subunits α,β,β’,ω + GREB + RNA + DNA – Cryo EM
    
  • 5tbz - EcRNAP subunits α,β,β’ + NusG – Cryo EM
    
  • 6fbv - MtuRNAP subunits α,β,β’,ω + σ factor – single particle EM
    
  • 5zx3 - MtuRNAP subunits α,β,β’,ω + σ factor
    
  • 6dve, 6dvd, 6dvc, 6dvb, 6dv9 - MtuRNAP subunits α,β,β’,ω + σ factor + DNA
    
  • 5zx2 - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA
    
  • 3ihq, 1z3e, 3gfk - BsRNAP subunit α + regulatory protein SPX
    
  • 1l9u - TaRNAP subunits α,β,β’,ω + σ factor
    
  • 2jzb – RNAP subunit α + NusA transcription elongation factor – Yersinia pseudotuberculosis
    
  • 3tbi - RNAP subunit β + GP33 – Enterobacteria phage T4
    
  • 3lpe- MjRNAP subunit ε’’ + transcription antitermination protein
    
  • 6eyd - MsRNAP subunits α,β,β’,ω + σ factor – Cryo EM
    
• Prokaryotic DNA-dependent RNAP complex with σ factor + DNA/RNA
  • 4oin, 4oio - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA
    
  • 4oip - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA + nucleotide
    
  • 4oiq, 4oir - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA + antibiotic
    
  • 4g7h, 4g7o, 4g7z, 4q4z, 5d4d, 5d4e, 5voi, 6p70 - TtRNAP subunits α,β,β’,ω + σ factor + DNA
    
  • 4q5s, 5d4c, 5e17, 5e18, 5vo8, 6p71, 6oy7, 6oy6, 6oy5, 6ow3, 6ovy, 6ovr - TtRNAP subunits α,β,β’,ω + σ factor + DNA + RNA
    
  • 5i2d - TtRNAP subunits α,β,β’,ω + σ factor + transcriptional regulator + DNA + RNA
    
  • 6cuu - TtRNAP subunits α,β,β’,ω + σ factor + DNA + antibiotic
    
  • 6n62 - EcRNAP subunits α,β,β’,ω + σ factor + DNA
    
  • 6n61 - EcRNAP subunits α,β,β’,ω + σ factor + DNA + capistruin peptide
    
  • 6n60 - EcRNAP subunits α,β,β’,ω + σ factor + DNA + microcin peptide
    
  • 5nsr, 5nss, 6gh6, 6gh5, 6ca0, 6omf - EcRNAP subunits α,β,β’,ω + σ factor + DNA – Cryo EM
    
  • 5vt0 - EcRNAP subunits α,β,β’,ω + σ factor + RNA – Cryo EM
    
  • 4yln, 4ylo, 4ylp, 5ipl, 5ipm, 5ipn, 6gfw - EcRNAP subunits α,β,β’,ω + σ factor + DNA + RNA
    
  • 6b6h - EcRNAP subunits α,β,β’,ω + σ factor + CAP + DNA + RNA – Cryo EM
    
  • 6k4y - EcRNAP subunits α,β,β’,ω + σ factor + anti-s factor + MOTA + DNA – Cryo EM
    
  • 3iyd - EcRNAP subunits α,β,β’,ω + σ factor + catabolite gene activator + DNA
    
  • 4s20 - EcRNAP subunits α,β,β’,ω + σ factor + RAPA + DNA
    
  • 5ms0 - EcRNAP subunits α,β,β’,ω + σ factor + NusB + NusG + NusA + antitermination protein + RS10 + DNA – Cryo EM
    
  • 5uha - MtuRNAP subunits α,β,β’,ω + σ factor + DNA
    
  • 5uh9, 5uh8, 6jcy, 6jcx, 6jbq - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA
    
  • 5uhg, 5uhc, 5uh6, 5uh5 - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA + antibiotic
    
  • 5uhd, 5uhb - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + antibiotic
    
  • 5uhf, 5uhe - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA + inhibitor
    
  • 1l9z - TaRNAP subunits α,β,β’,ω + σ factor + DNA
    
• Prokaryotic DNA-dependent RNAP complex with protein + DNA/RNA
  • 3aoh, 3aoi - TtRNAP subunits α,β,β’,ω + DNA + RNA + GFH1
    
  • 3t72 - EcRNAP subunit β + Pho box DNA + PhoB
    
  • 1lb2, 3n4m - EcRNAP subunit α + DNA + CAP
    
  • 1xs9 - EcRNAP subunit α + DNA + MARA
    
  • 5ciz - EcRNAP subunit α + DNA + CRP
    
  • 3n97 - EcRNAP subunit α C terminal + DNA + σ factor
    
  • 6c6u - EcRNAP subunits α,β,β’,ω + NusG + DNA – Cryo EM
    
  • 6c6t, 6c6s - EcRNAP subunits α,β,β’,ω + RFAH + DNA – Cryo EM
    
  • 6gov - EcRNAP subunits α,β,β’,ω + NusB + antitermination protein + RS10 + DNA – Cryo EM
    
  • 6flq - EcRNAP subunits α,β,β’,ω + NusA + DNA + RNA – Cryo EM
    
  • 6alg - EcRNAP subunits α,β,β’,ω + NUN + DNA + RNA – Cryo EM
    
  • 6p19 - EcRNAP subunits α,β,β’,ω + protein Q + DNA + RNA – Cryo EM
    
  • 6jnx - EcRNAP subunits α,β,β’,ω + protein Q + σ factor + DNA – Cryo EM
    
  • 6p18 - EcRNAP subunits α,β,β’,ω + protein Q + σ factor + DNA + RNA – Cryo EM
    
  • 6j9f - XoRNAP subunits α,β,β’,ω + P7 + DNA + RNA – Xanthomonas oryzae - Cryo EM
    
  • 6j9e - XoRNAP subunits α,β,β’,ω + P7 + DNA + RNA + NusA - Cryo EM
    
• Prokaryotic DNA-dependent RNAP complex with small molecule
  • 1zyr, 2a68, 2a69, 2a6e, 2a6h - TtRNAP subunits α,β,β’,ω + antibiotic
    
  • 1i6v, 1ynj, 1ynn - TaRNAP subunits α,β,β’,ω + antibiotic
    
• Viral DNA-dependent RNAP
  • 6ric – VvRNAP – vaccinia virus – Cryo EM
    
  • 6rid – VvRNAP + RNA + DNA – Cryo EM
    
  • 6rie – VvRNAP + mRNA capping enzyme + RNA + DNA – Cryo EM
    
• Eukaryotic DNA-dependent RNAP I
  • 1a1d – yRNAP subunit RPB8 – yeast - NMR
    
  • 2rf4 - yRNAP I subunit RPA4
    
  • 5g5l, 5lmx, 5m3f, 5m3m, 5m5w, 5m5x, 5m5y, 5m64 – yRNAP I – Cryo EM
    
  • 5n5y, 5n5z, 5n60, 5oa1 – yRNAP I + RRN – Cryo EM
    
  • 5n61, 6h68, 6h67 – yRNAP I + RRN + DNA + RNA – Cryo EM
    
  • 5w66, 5w65, 5w64, 5w5y – yRNAP I + transcription initiation factor + DNA + RNA – Cryo EM
    
• Eukaryotic DNA-dependent RNAP II
  • 1qkl - hRNAP II subunit RPB6 - human
    
  • 2c35 - hRNAP II subunits RPB4 RPB7 (mutant) – NMR
    
  • 2f3i - hRNAP II subunits RPB8 RPB17 RPABC3 – NMR
    
  • 2ghq, 2ght - hRNAP II subunits RPB1 + hRNAP II C terminal
    
  • 2q5e, 3l0b, 3l0c - hRNAP II C terminal
    
  • 1nik, 1nt9, 1wcm, 2b8k, 3fki, 3qt1, 1i3q, 1i50, 1dzf, 5ip7, 5ip9, 5u5q – yRNAP II
    
  • 4x67, 4x6a, 4y52, 4y7n, 5c3e, 5c44, 5c4a, 5c4j, 5c4x, 6bqf, 6bm4, 6bm2, 6blp, 6blo, 5w51, 5w4u – yRNAP II + DNA + RNA
    
  • 6inq, 6a5u, 6a5t, 6a5r, 6a5p, 6a5o, 6a5l – yRNAP II + DNA + RNA + histones – Cryo EM
    
  • 3j1n, 4v1n, 5fmf, 5x51, 5x50, 5x4z – yRNAP II – Cryo EM
    
  • 1y14 - yRNAP II subunits RPB4 RPB7
    
  • 5flm – bRNAP II + DNA + RNA - bovine
    
  • 5oik – bRNAP II + SPT4 + SPT5 + DNA + RNA
    
  • 3ef0, 3ef1 - fyRNAP II subunit α C terminal – fission yeast
    
  • 3h0g – fyRNAP II
    
  • 5u0s – fyRNAP II + mediator complex – Cryo EM
    
• Eukaryotic DNA-dependent RNAP II complex with DNA/RNA
  • 4boc – hRNAP + DNA
    
  • 1i6h, 4a3i - yRNAP II + DNA
    
  • 4v1m - yRNAP II + DNA – Cryo EM
    
  • 1r9s, 2ja5, 2ja6, 2ja7, 2ja8, 2nvq, 2nvt, 2nvx, 2nvy, 2nvz, 3gtg, 3gtj, 3gtk, 3gtl, 3gtm, 3gto, 3gtp, 3gtq, 3hov, 3how, 3hox, 3hoy, 3hoz, 3po2, 3po3, 3m3y, 3m4o, 4a3g, 4a93, 4a3b, 4a3c, 4a3d, 4a3e, 4a3f, 4a3j, 4a3k, 4a3l, 4a3m - yRNAP II + RNA + DNA
    
  • 5vvs - yRNAP II + RNA + DNA – Cryo EM
    
  • 1y1w, 1y77, 2r7z, 2r92, 2r93, 3h3v, 3rzd, 3rzo, 3s15, 3s16, 3s17, 3s1m, 3s1n, 3s1q, 3s1r, 3s2d, 3s2h - yRNAP II + RNA
  • 2b63 - yRNAP II + nucleotide + RNA
    
  • 2e2i, 2e2j - yRNAP II + nucleotide + DNA
    
  • 2yu9, 3i4m, 3i4n - yRNAP II + nucleotide + DNA + RNA
    
  • 2vum - yRNAP II + inhibitor + DNA + RNA
    
• Eukaryotic DNA-dependent RNAP II complex with protein
  • 3o2q, 3o2s – hRNAP II subunit α C-terminal + symplekin
    
  • 3j0k, 5iy6, 5iy7, 5iy8, 5iy9, 5iya, 5iyb, 5iyc, 5iyd – hRNAP II + TFIIF – Cryo EM
    
  • 2lto - hRNAP II subunit RPB1 + Tudor domain containing protein 3
    
  • 1pqv, 1y1v, 4bbr, 4bbs - yRNAP II + TFIIS
    
  • 1y1y - yRNAP II + TFIIS + DNA +RNA
    
  • 1r5u, 3k7a, 3k1f - yRNAP II + TFIIB
    
  • 4v1o, 5fyw, 5fz5, 5sva - yRNAP II + DNA + TIIF + TBP + mediator – Cryo EM
    
  • 2l0i – yRNAP C-terminal + RTT103 – NMR
    
  • 4bxx, 4bxz, 4by1, 4by7 – yRNAP II + RNA + DNA + transcription factor Bye1
    
  • 5vvr - yRNAP II + DNA + RNA + Rad26 – Cryo EM
    
  • 6gml – pRNAP II + RNA + DNA + DSIF + NELF – pig – Cryo EM
    
  • 6gmh – pRNAP II + RNA + DNA + DSIF + PAF + SPT6 – Cryo EM
    
  • 6exv – pRNAP II + RNA + DNA + amatoxin – Cryo EM
    
• Eukaryotic DNA-dependent RNAP II complex with small molecule
  • 3pgl - hRNAP II C terminal + inhibitor
    
  • 3cqz, 1k83 - yRNAP II + inhibitor
    
  • 1twa, 1twc, 1twf, 1twg, 1twh - yRNAP II + nucleotide
    
• Eukaryotic DNA-dependent RNAP III
  • 2xub, 2xv4 - hRNAP III subunits RPC3
    
  • 5afq - hRNAP III subunits RPC3 + RPC32B
    
  • 2dk8 – RNAP III RPC34 domain - mouse – NMR
    
  • 2dk5 – hRNAP III winged helix domain (mutant) – NMR
    
  • 2yu3 - hRNAP III winged helix domain
    
  • 2ckz, 5fj9, 5fja, 6eu3, 6eu2 - yRNAP III - Cryo EM
    
  • 5fj8, 6f41 - yRNAP III + DNA + RNA - Cryo EM
    
  • 6f44, 6f42, 6f40, 6eu1 - yRNAP III + DNA – Cryo EM
    
  • 6cnf, 6cnd, 6cnc, 6cnb - yRNAP III + DNA + TFIIIB – Cryo EM
    
  • 5xon - yRNAP III + DNA + RNA + TFIIB + SPT4 + SPT5 – Cryo EM
    
  • 5xog - yRNAP III + DNA + RNA + SPT5 + KOW5 + ELF1 – Cryo EM
    
  • 6eu0 - yRNAP III + DNA + TFIIIB + TATA-box-binding protein – Cryo EM
    
  • 3ayh - fyRNAP III subunit Rpc8+Rpc9
    
• Eukaryotic DNA-dependent RNAP I+II+III
  • 6o9l, 6drd - hRNAP – Cryo EM
    
  • 6rwe, 6ruo, 6rui, 6rrd, 6rqt, 6rql, 6rqh, 6o6c, 6hls - yRNAP – Cryo EM
    
  • 6hlr, 6hlq, 6hko - yRNAP + nucleotide analog – Cryo EM
    
  • 6j51, 6j50, 6j4z, 6j4y, 6j4x, 6j4w, 6ir9 - yRNAP + Elf1 + Spt4 + Spt5 + histones – Cryo EM
    
  • 6i84 - yRNAP + DNA + histones – Cryo EM
    
  • 6gyl, 6gym, 6gyk - yRNAP + DNA + TBP + transcription initiation factors – Cryo EM
    
• Eukaryotic DNA-dependent RNAP μ or DNA-directed DNA/RNA polymerase mu
  • 4lzd – hRNAP μ
    
  • 4lzg, 4m04, 4m0a, 5twp, 5twq, 5twr, 5tws. 5txx, 5txz, 5tyb, 5tyc, 5tyd, 5tye, 5tyf, 5tyg, 5tyu, 5tyv, 5tyw, 5tyx, 5tyy, 5tyz, 6p1w, 6p1v, 6p1u, 6p1t, 6p1s, 6p1r, 6p1q, 6p1p, 6p1o, 6p1n, 6p1m, 6akh, 6ak9, 6ak8 – hRNAP μ + DNA
    
  • 5vzi, 5vzh, 5vzg, 5vzf, 5vze, 5vzd, 5vzc, 5vzb, 5vza, 5vz9, 5vz8, 5vz7, 6ipg, 6ipf, 6ipe, 6ipd – hRNAP μ (mutant) + DNA + nucleotide
    
  • 5zlc – hRNAP μ + nucleotide
    
  • 6ipn, 6ipm, 6ipl, 6ipk, 6ipj, 6ipi, 6iph, 6ak6, 6ak5, 6aeh, 6aec – hRNAP μ (mutant) + nucleotide
    
• Eukaryotic DNA-dependent RNAP mitochondrial
  • 4boc – hRNAP + DNA
    
  • 6erq, 6erp – hRNAP + DNA + MTTFA + dimethyladenosine transferase
    
  • 3spa - hRNAP + polypeptide
    
• Eukaryotic DNA primase
  • 4lik, 4mhq, 6rb4 - hDNAP small subunit
    
  • 3q36 – hDNAP large subunit
    
  • 5i7m – hDNAP large subunit (mutant)
    
  • 3l9q – hDNAP large subunit P58C domain
    
  • 5dqo – hDNAP large subunit P58C domain (mutant)
    
  • 4rr2 - hDNAP small + large subunit
    
  • 4bpu - hDNAP small (mutant) + large subunit
    
  • 4ehs – HpDNAP C terminal
    
  • 4lim, 4mm2 - yDNAP small subunit
    
  • 3lgb, 6di6, 6dhw - yDNAP large subunit Fe-S domain
    
  • 6du0, 6dtz, 6dtv, 6di2 - yDNAP large subunit Fe-S domain (mutant)
    
• Eukaryotic DNA primase complex
  • 4lil - hDNAP small subunit + UTP
    
  • 6r4s - hDNAP small subunit + ATP
    
  • 6r5e, 6r5d, 6r4u, 6r4t - hDNAP small subunit + nucleoside analog
    
  • 5f0s, 5f0q – hDNAP large subunit C terminal + RNA
    
  • 4bpw - hDNAP small (mutant) + large subunit + UTP
    
  • 4bpx - hDNAP small (mutant) + DNA polymerase α catalytic subunit
    
  • 5exr - hDNAP small + large subunits + DNA polymerase α catalytic subunit
    
• Bacterial DNA primase
  • 1d0q - GsDNAP zinc-binding domain - Geobacillus stearothermophilus
    
  • 1z8s - GsdnaG dnaB binding domain - NMR
    
  • 2haj - EcdnaG catalytic domain - NMR
    
  • 1t3w – EcdnaG C-terminal
    
  • 1eqn, 1dd9, 1dde – EcdnaG catalytic core
    
  • 5w33 - MtudnaG RPD 112-432
    
  • 5z51 - MtudnaG helicase-binding domain 482-637
    
  • 5vaz – dnaG – Pseudomonas aeruginosa
    
  • 4im9 – VcdnaG C-terminal
    
  • 3m1m – DNAP RNA polymerase domain – Sulfolobus islandicus
    
  • 1zt2, 2pa8, 2pmz, 3hkz, 5ofn - SsDNAP small + large subunit – Sulfolobus solfataricus
    
  • 2au3 – DNAP zinc-binding and RNAP domains – Aquifex aeolicus
    
  • 1v33 - PhDNAP small subunit – Pyrocuccus horikoshii
    
  • 1g71 - PfDNAP small subunit
    
  • 4e2k – SaDNAP – Staphylococcus aureus
    
  • 2lzn – SaDNAP C terminal – NMR
    
  • 5guj – BsdnaG RNAP domain
    
• Bacterial DNA primase complex
  • 2r6a, 2r6c - GsdnaG helicase binding domain + helicase
    
  • 4m4w - GsdnaG helicase binding domain + helicase + DnaI
    
  • 3b39 – EcdnaG catalytic domain + DNA
    
  • 5w36, 5w35, 5w34 - MtudnaG + DNA
    
  • 1v34 - PhDNAP small subunit + UTP
    
  • 4edg, 4edk, 4edr, 4edt, 4edv, 4ee1 – SaDNAP + nucleotide
    
  • 5of3 - SsDNAP small + large subunit + protein
    
• RNA polymerase from Bacteriophage T7 or DNA primase/helicase or GP4
  • 1q57 – T7DNAP/helicase (mutant) – Enterobacteria phage T7
    
  • 1nui – T7DNAP/helicase primase fragment (mutant)
    
  • 1cr0 - T7DNAP/helicase helicase domain
    
  • 1cr1, 1cr2, 1cr4 - T7DNAP/helicase helicase domain + nucleotide
    
  • 4rnp – T7RNAP
    
  • 1aro – T7RNAP + T7 lysozyme
    
  • 1cez, 1h38, 1qln, 2pi4, 2pi5 - T7RNAP + DNA
    
  • 6n7v, 6n7t, 6n7s, 6n7n, 6n7i - T7RNAP (mutant) + DNA + TTP – Cryo EM
    
  • 1msw, 1s0v, 1s76, 1s77, 3e2e, 3e3j - T7RNAP + DNA + RNA
    
  • 6n9x, 6n9w, 6n9v, 6n9u - T7RNAP (mutant) + GP5 + DNA + RNA – Cryo EM
    
  • 5ikn - T7RNAP (mutant) + GP5 + thioredoxin
    
• RNA-dependent RNAP
  • 3phu, 1khv, 1khw – HfRNAP L RNA-directed – Hemorrhagic fever virus
    
  • 5v5i, 5v5h, 5v5g – HfRNAP L + ubiquitin
    
  • 2xwh, 2xxd, 2xhu,2xhw, 3i5k, 1c2p, 1csj, 1quv, 1yuy, 1yv2, 1yvx, 1yvz, 3gsz, 4aep, 4aex, 2wrm, 3mwv, 3mww – HvRNAP Ns5b domain – Hepatitis virus
    
  • 3vc8 - HvRNAP cytoplasmic domain C terminal
    
  • 3vcb, 4ry4, 4ry5, 4ry6, 4ry7 - HvRNAP cytoplasmic domain C terminal (mutant)
    
  • 2xym, 2xhv, 2xi2, 4e76, 4adp, 4obc, 4wt9 - HvRNAP Ns5b domain (mutant)
    
  • 1rdr - PoRNAP – Polio virus
    
  • 1tql, 2ijd, 2ijf, 4nlo, 4nlp, 4nlq, 4nlr, 4nls, 4nlt, 4nlu, 4nlv, 4nlw, 4nlx, 4nly, 4r0e - PoRNAP (mutant)
    
  • 2xi5, 2xi7 – BvRNAP L N-terminal – Bunyavirus
    
  • 3jsb – RNAP (mutant) – Lymphocytic choriomengitis virus
    
  • 2wk4, 2uut, 2uuw – SvRNAP (mutant) – Sapporo virus
    
  • 2ckw - SvRNAP residues 1135-1649
    
  • 3nky, 4wyl, 4wyw, 6gvv - FmRNAP (mutant) - Foot-and-mouth virus
    
  • 1hhs, 4a8o, 4b02, 1hi8, 5fj6 – P6RNAP – Bacteriophage φ-6
    
  • 2jl9, 2jlf, 1wac – P6RNAP (mutant)
    
  • 5fj7 – P6RNAP + major inner protein P1
    
  • 2po4 – N4RNAP polymerase domain – Bacteriophage N4
    
  • 1l9k – DevRNAP N terminal – Dengue virus
    
  • 2j7u, 4c11 - DevRNAP polymerase domain
    
  • 5ccv - DevRNAP NS5
    
  • 1oks – RNAP α subunit – Measles virus
    
  • 1r4g - RNAP α subunit – Sendai virus – NMR
    
  • 1s48, 1s49, 1s4f – DvRNAP residues 71-679 – Diarrhea virus
    
  • 2cjq - DvRNAP polymerase domain
    
  • 1sh0, 1sh2, 1sh3 - NvRNAP C terminal – Norwalk virus
    
  • 1vyi - RNAP α subunit C terminal – Rabies virus
    
  • 2hcn, 2hcs, 2hfz – RNAP polymerase domain – West Nile virus
    
  • 2pgg, 2pus – RNAP – Bursal disease virus
    
  • 2r7o, 2r7q – SrRNAP – Simian rotavirus
    
  • 4au6 - RNAP – bovine rotavirus – Cryo-EM
    
  • 2yi8, 2yi9, 2yia, 2yib – IpnvRNAP – Infectious pancreatic necrosis virus
    
  • 3n6l – EvRNAP – Human enterovirus
    
  • 4uci, 4ucj, 4ucl, 4ucy, 4ucz – HmpvRNAP L residues 1600-2005 – Human metapneumovirus
    
  • 4uck, 4ud0 – HmpvRNAP L residues 1600-2005 (mutant)
    
  • 4zp8, 4zp9, 4zpa, 4zpb, 4zpc, 4zpd – CvRNAP residues 1724-2185 (mutant) – Coxsackievirus
    
  • 3ddk – CvRNAP residues 1724-2185
    
  • 3nah, 3nai, 3qid, 3uqs – MnvRNAP – Murine norovirus
    
  • 4wfx, 4wfy, 4wfz – CvRNAP RDRP domain (mutant)
    
  • 2j7n, 2j7o – RNAP residues 381-1402 – Neurospora crassa
    
  • 4gzk, 4ieg – RNAP – cystovirus 12
    
  • 4i1t – RNAP L – Pichinde virus
    
  • 5chs – RNAP L N-terminal – Vescicular stomatitis Indiana virus
    
  • 4xha, 4xhi – TavRNAP – Thosea asigna virus
    
  • 4miw, 5izh, 5j1n, 5j1p – RNAP L N terminal – Lassa virus
    
  • 4mtp – RNAP RDRP module – Encephalitis virus
    
  • 4cgx, 4chc – TvRNAP N terminal – Thogoto virus
    
  • 4chd – TvRNAP 627 domain
    
  • 4che, 4chf – TvRNAP cap-binding domain
    
  • 5fsw - NvRNAP C terminal – Thielavia terrestris
    
  • 6q99 – RNAP – Andes virus
    
  • 5ize – RNAP L – Hantaan virus
    
  • 5ltf – LcmvRNAP L – Lymphocytic choriomeningitis mammarenavirus
    
  • 5lts - LcmvRNAP (mutant)
    
  • 5u0c - ZvRNAP NS5 – Zika virus
    
  • 6qw5, 6qw0, 6qvv - RNAP – Toscana virus
    
  • 6dx5 - RNAP OTU domain – Farallon virus
    
  • 6dx3 - RNAP OTU domain – Taggert virus
    
  • 6dx2 - RNAP OTU domain – Dera Ghazi khan virus
    
  • 6dx1, 6dwx - RNAP OTU domain – Qulybus virus
    
• RNA-dependent RNAP complex with RNA
  • 4e78, 4e7a, 4wta, 4wtc, 4wtd, 4wte, 4wtf, 4wtg, 4wti, 4wtj, 4wtk, 4wtl, 4wtm - HvRNAP Ns5b domain (mutant) + RNA
    
  • 3ol6, 2jlg, 4k4s, 4k4t, 4k4u, 4k4v, 4k4w – PoRNAP (mutant) + RNA
    
  • 3ol7, 3ol8, 3ol9, 3ola, 3olb - PoRNAP (mutant) + RNA + nucleotide
    
  • 3klv, 3kmq, 3kms, 3kna, 3nl0, 3nma, 4iqx, 4wzm, 4wzq, 4x2b, 5jxs – FmRNAP (mutant) + RNA
    
  • 3koa - FmRNAP (mutant) + RNA + nucleotide
    
  • 1wne – FmRNAP + RNA
    
  • 2e9r, 2e9t, 2e9z, 2ec0 - FmRNAP + RNA + inhibitor
    
  • 1uvi, 1uvl, 1uvm, 1uvn, 4a8f, 4a8k, 4a8m, 4a8q, 4a8s, 4a8w, [[4a8y – P6RNAP + RNA
    
  • [[3bsn, 3bso, 3h5x, 3h5y - NvRNAP + RNA + nucleotide
    
  • 2r7r, 2r7s, 2r7t, 2r7u, 2r7v, 2r7w, 2r7x – SrRNAP + RNA
    
  • 5amq, 5amr – BvRNAP + RNA
    
  • 4k50 – RNAP + RNA – Human rhinovirus
    
  • 3c2p, 3c3l, 3c46, 3q0a - N4RNAP polymerase domain + promoter DNA
    
  • 1hht, 1hi0 – P6RNAP + DNA
    
  • 1uvj, 1uvk – P6RNAP + RNA
    
  • 4k4x, 4k4y, 4k4z – CvRNAP + RNA
    
  • 6ogz – RvaRNAP + RNA – Rotavirus A – Cryo EM
    
  • 6kwq – EvRNAP + RNA
    
  • 6kwr – EvRNAP + RNA + CMP + CTP
    
• RNA-dependent RNAP complex with protein
  • 3phw, 2pt2, 3pt2 – HfRNAP + ubiquitin
    
  • 3phx, 3pse – HfRNAP + ISG15
    
  • 6u5o – HmpvRNAP L + phosphoprotein – Cryo EM
    
  • 6pzk – RNAP L + phosphoprotein – Human respiratory syncytial virus - Cryo EM
    
  • 6po2, 6pns – RNAP + VP3 – Bluetongue virus - Cryo EM
    
  • 2d7s, 2f8e – FmRNAP + VPG
    
  • 5y3d – MnvRNAP + VPG
    
  • 3cdw - CvRNAP + POP + VPG
    
  • 4f5x – SrRNAP + Vp2 + Vp6
    
  • 3zed – IpnvRNAP + capsid protein Vp3
    
  • 4hxd – RNAP L + polyubiquitin-C – Dugbe virus
    
  • 4r71 – RNAP b chain + EF-TS EF-TU + RPS1 – Enterobacteria phage qbeta
    
  • 5jze – RNAP + ISG15 – Erve virus
    
  • 6tz0, 6ty8 – BmcpvRNAP + Vp4 – Bombyx mori cytoplasmic polyhedrosis virus – Cryo EM
    
  • 6tz2, 6tz1, 6ty9, 5h0r – BmcpvRNAP + Vp4 – RNA – Cryo EM
    
  • 6ogy – RvARNAP + Vp2 + RNA – Cryo EM
    
  • 6k32 – RvARNAP + Vp1 + Vp4 + RNA – Cypovirus 1 - Cryo EM
    
• RNA-dependent RNAP complex with small molecule
  • 2xwy, 3mf5, 3hkw, 3hky, 3lkh, 3gnv, 3gnw, 3h98, 3g86, 3h59, 1nhu, 1nhv, 2brk, 2brl, 2gc8, 2giq, 2gir]], 2hai, 2hwh, 2hwi, 2i1r, 2ijn, 2jc0, 2jc1, 2qe2, 2qe5, 2wcx, 2who, 3ciz, 3cj0, 3cj2, 3cj3, 3cj4, 3cj5, 3cso, 3cvk, 3fqk, 3fql, 3gol, 3h5s, 3h5u, 3q0z, 3qgd, 3qge, 3qgf, 3qgg, 3qgh, 3qgi, 3ska, 3ske, 3skh, 3uph]], 3upi, 4dru, 3vqs, 3udl, 4eo6, 4eo8, 4eaw, 4gmc, 4ih5, 4ih6, 4ih7, 4iz0, 4jtz, 4jtw, 4jty, 4ju1, 4ju2, 4jjs, 4jju, 4j02, 4j04, 4j06, 4j08, 2yoj, 3tuq, 3tuv, 3u4o, 3u4r, 4mk7, 4mk8, 4mk9, 4mka, 4mkb, 4mz4, 4nld, 3tyq, 3tyv, 4mia, 4mib, 4oow, 4tlr, 5pzk, 5pzl, 5pzm, 5pzn, 5pzo, 5pzp, 5trh, 5tri, 5trj - HvRNAP Ns5b domain + inhibitor
    
  • 3gyn, 1os5, 3br9, 3bsa, 3bsc, 3cde, 3co9, 3cwj, 3d28, 3d5m, 3e51, 3frz, 3igv, 3hvo, 3h2l, 4kai, 4kb7, 4kbi, 4ke5, 4khm, 4khr, 5twm, 5twn - HvRNAP Ns5b domain (mutant) + inhibitor
    
  • 2xi3 - HvRNAP Ns5b domain (mutant) + GTP
    
  • 1gx5, 1gx6 - HvRNAP Ns5b domain + nucleotide
    
  • 2im1, 2im0, 2im2, 2im3, 2ily, 2ilz - PoRNAP (mutant) + nucleotide
    
  • 3n6m, 3n6n – EvRNAP + nucleotide
    
  • 3sfg – MnvRNAP + thio-uridine
    
  • 3sfu – MnvRNAP + ribavirine
    
  • 3upf, 3ur0, 4nru, 4o4r – MnvRNAP + inhibitor
    
  • 4lq3, 4lq9 – RNAP + inhibitor – human norovirus
    
  • 3cdu– CvRNAP + POP
    
  • 3eva, 3evb, 3evc, 3evd, 3eve, 3evf, 3evg – RNAP N terminal + SAH – Yellow fever virus
    
  • 1hi1 – P6RNAP + NTP
    
  • 5cx6, 5cyr - TavRNAP + nucleotide
    
  • 5hmw, 5f3t, 5hmx, 5hmy, 5hn0, 5hmz, 5iq6, 5k5m - DevRNAP Ns5 + inhibitor
    
  • 5ehg - DevRNAP NS5 + SAM + inhibitor
    
  • 5goz, 5gp1 - ZvRNAP NS5 + SAH + GTP
    
  • 5ltn, 5t2t - LcmvRNAP + inhibitor
    
  • 6mvo – RNAP (mutant) + inhibitor – Hepacivirus C
    
• Influenza virus polymerase acidic protein (or PA or subunit P2) N terminal 1-198
  • 4p9a, 4nfz, 4avq, 4e5e, 4zqq, 5jht, 5jhv, 5des - IvRNAP PA N terminal – Influenza virus
    
  • 5d2o, 5czn, 3hw6, 6fsb - IvRNAP PA N terminal (mutant)
    
  • 3ebj, 2w69 - IvRNAP PA residues 1-256
    
  • 4iuj - IvRNAP PA residues 254-713
    
  • 3hw3, 3hw4, 3hw5 - IvRNAP PA residues 1-256 (mutant) + Mn + nucleotide
    
  • 4w9s, 5fdd, 5fdg, 5i13, 5ieq, 5if2, 5if5, 5if7, 5if8, 5ifb, 5ifc, 5ifd, 5wa6, 5wa7, 5wb3, 5wap, 5w9g, 5w92, 5w44, 5v0u, 6nem, 6nel, 6e6x, 6e6w, 6e6v, 6dcz, 6dcy, 5ega, 5cl0, 5cgv, 5ccy, 4mk5, 4mk2, 4mk1, 4awm, 4awk, 4awh, 4awg, 4awf, 4e5f, 4e5g, 4e5h, 4e5i, 4e5j, 4e5l, 4yyl, 4zhz, 4zi0, 6fs7, 6fs6, 6fs8, 4avl, 4avg – IvRNAP PA N terminal + inhibitor
    
  • 5wg9, 5wfz, 5wfw, 5wfm, 5wf3, 5wei, 5wef, 5web, 5we9, 5we7, 5wdw, 5wdn, 5wdc, 5wct, 5wcs, 5w73, 5w7u, 5w3i, 5vrj, 5vqn, 5vpx, 5vpt, 5vp8, 6e4c, 6e3p, 6e3o, 6e3n, 6e3m, 6e0q, 6dzq, 5deb, 5dbs, 5d9j, 5d8u, 5d4g, 5d42, 6fs9 – IvRNAP PA N terminal (mutant) + inhibitor
    
• Influenza virus polymerase basic protein 2 (or RNAP subunit P3 or PB2)); Domains: cap-binding 318-483; Cap-binding and midlink 247-536; 627 538-693; NLS 694-753
  • 4enf, 4u6o, 4j2r, 2vqz, 5ef9, 5eg9 – IvRNAP PB2 cap-binding domain
    
  • 3wi0 – IvRNAP PB2 cap-binding domain (mutant)
    
  • 3cw4 - IvRNAP PB2 627 + NLS domains
    
  • 2gmo - IvRNAP PB2 627 + NLS domains - NMR
    
  • 4eqk, 5efa, 5efc – IvRNAP PB2 cap-binding domain + GTP
    
  • 4nce, 3wi1 – IvRNAP PB2 cap-binding domain (mutant) + GTP derivative
    
  • 4ncm – IvRNAP PB2 cap-binding domain (mutant) + inhibitor
    
  • 4p1u, 4yd0, 5buh, 5jun, 5jur - IvRNAP PB2 cap-binding domain + inhibitor
    
  • 6euy, 6eux, 6euv - IvRNAP PB2 cap-binding + midlink domains + inhibitor
    
  • 5wl0 - IvRNAP PB2 cap-binding + midlink + 627 + NLS domains + inhibitor
    
  • 4uad, 4uae, 4uaf - IvRNAP PB2 + importin
    
  • 2vy6 - IvRNAP PB2 627 + NLS domains
    
  • 2vy7 - IvRNAP PB2 627 domain
    
  • 2vy8 - IvRNAP PB2 627 domain (mutant)
    
• Influenza virus RNAP PA+PB1
  • 2znl - IvRNAP PA + PB1
    
  • 3cm8 - IvRNAP PA residues 256-716 + PB1 peptide
    
• Influenza virus RNAP PA+PB2
  • 5fml - IvRNAP PA N terminal + PB2 NLS peptide
    
• Influenza virus RNAP PB1+PB2
  • 2ztt, 3a1g - IvRNAP PB1 C terminal + RNAP PB2 N terminal
    
  • 3j9b - IvRNAP PB1+PB2 N terminal + RNA
    
• Influenza virus RNAP PA+PB1+PB2 (subunits P1+p2+p3)
  • 6qpf, 6qnw, 5d98, 5d9a - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2
    
  • 6kv5 - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 – Cryo EM
    
  • 4wsb, 5fmz, 5m3h, 5m3j, 5msg, 6f5o, 6evj, 6qcx, 6qcw, 6fhi, 4wrt, 4wsa - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA
    
  • 6rr7, 6qx8, 6qwl, 6qct, 6qcs, 6kuv, 6kuu, 6kut, 6kur, 6kup, 6kuk, 6kuj - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA – Cryo EM
    
  • 6qpg - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA + nanobody
    
  • 6qxe, 6qx3 - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA + nanobody – Cryo EM
    
  • 6evk - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA + GTP
    
  • 6qcv - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA + CTP
    
  • 6f5p - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + polyAla
    
  • 6fhh - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + POL II peptide
    
• Poly(A) RNA polymerase
  • 3pq1 – hRNAP (mutant)
    
  • 4lt6 – hRNAP γ
    
  • 4nkt – SpRNAP (mutant) + UMPNPP
    
  • 4nku – SpRNAP (mutant) + RNA
    
  • 3nyb – yRNAP + AIR2
    
  • 4e7x, 4e80, 4e8f, 4ep7, 4fh3 – fyRNAP Cid1
    
  • 4fh5, 4fhp, 4fhv, 4fhw, 4fhy – fyRNAP Cid1 + nucleotide
    
  • 4ud4, 4ud5 - fyRNAP Cid1 (mutant)
    
  • 4fhx – fyRNAP Cid1 (mutant) + ATP
    
  • 4zrl – CeRNAP gld-2 + germline development defective 3 – Caenorhabidis elegans
    
  • 5jnb – CeRNAP gld-2 (mutant) + RNP-8
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman