DNA polymerase 3D structures: Difference between revisions

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*DNA polymerase gamma
*DNA polymerase gamma


**[[3ikm]] - hDpo 1+2 <br />
**[[3ikm]] - hDpo gamma1+gamma2 <br />
**[[8v5d]] - hDpo1 – Cryo EM<br />
**[[8v5d]] - hDpo gamma1 – Cryo EM<br />
**[[3ikl]], [[2g4c]] - hDpo 2<br />
**[[3ikl]], [[2g4c]] - hDpo gamma2<br />
**[[2jw5]] - hDpo BRCT domain<br />
**[[2jw5]] - hDpo gamma BRCT domain<br />
**[[1xsl]] - hDpo catalytic domain<br />
**[[1xsl]] - hDpo gamma catalytic domain<br />
**[[1nzp]] - hDpo lyase domain - NMR<br />
**[[1nzp]] - hDpo gamma lyase domain - NMR<br />
**[[3pmn]], [[3pnc]], [[3mda]], [[2gws]], [[2bcq]], [[2bcr]], [[2bcs]], [[2bcu]], [[2bcv]], [[1xsp]], [[1rzt]] - hDpo + DNA<br />
**[[3pmn]], [[3pnc]], [[3mda]], [[2gws]], [[2bcq]], [[2bcr]], [[2bcs]], [[2bcu]], [[2bcv]], [[1xsp]], [[1rzt]] - hDpo gamma + DNA<br />
**[[8g5i]], [[8g5j]], [[8g5l]], [[8g5m]], [[8g5n]], [[8g5o]], [[8g5s]], [[8t7e]], [[8udl]], [[8v54]], [[8v5r]] - hDpo  + DNA – Cryo EM<br />
**[[8g5i]], [[8g5j]], [[8g5l]], [[8g5m]], [[8g5n]], [[8g5o]], [[8g5s]], [[8t7e]], [[8udl]], [[8v54]], [[8v5r]] - hDpo gamma1,2 + DNA – Cryo EM<br />
**[[8v55]] - hDpo (mutant) + DNA – Cryo EM<br />
**[[8v55]] - hDpo gamma1 (mutant),2 + DNA – Cryo EM<br />
**[[3mgh]], [[3c5f]], [[3c5g]], [[2pfn]] - hDpo (mutant) + DNA<br />
**[[3mgh]], [[3c5f]], [[3c5g]], [[2pfn]] - hDpo gamma (mutant) + DNA<br />
**[[8g5p]] - hDpo  + DNA + RNA – Cryo EM<br />
**[[8g5p]] - hDpo gamma1,2 + DNA + RNA – Cryo EM<br />
**[[3pml]], [[3mdc]], [[1xsn]], [[8udk]] - hDpo + DNA + nucleotide<br />
**[[3pml]], [[3mdc]], [[1xsn]], [[8udk]] - hDpo gamma + DNA + nucleotide<br />
**[[5c53]], [[5c52]], [[5c51]] - hDpo  + DNA + nucleotide + pyrimidine derivative<br />
**[[5c53]], [[5c52]], [[5c51]] - hDpo gamma1 + DNA + nucleotide + pyrimidine derivative<br />
**[[4ztz]], [[4ztu]] - hDpo  + DNA + nucleotide <br />
**[[4ztz]], [[4ztu]] - hDpo gamma1,2 + DNA + nucleotide <br />
**[[8d33]], [[8d37]], [[8d3r]], [[8d42]], [[9ggf]] - hDpo  + DNA + nucleotide – Cryo EM<br />
**[[8d33]], [[8d37]], [[8d3r]], [[8d42]], [[9ggf]] - hDpo gamma1,2 + DNA + nucleotide – Cryo EM<br />
**[[9ggb]], [[9ggc]], [[9ggd]], [[9gge]] - hDpo  (mutant) + DNA + nucleotide – Cryo EM<br />
**[[9ggb]], [[9ggc]], [[9ggd]], [[9gge]] - hDpo gamma1,2 (mutant) + DNA + nucleotide – Cryo EM<br />
**[[4k4g]], [[4k4h]], [[4k4i]] - hDpo + DNA + nucleotide analog<br />
**[[4k4g]], [[4k4h]], [[4k4i]] - hDpo gamma + DNA + nucleotide analog<br />
**[[3mgi]], [[3hw8]], [[3hwt]], [[3hx0]], [[2pfo]], [[2pfp]], [[2pfq]] - hDpo (mutant) + DNA + nucleotide<br />
**[[3mgi]], [[3hw8]], [[3hwt]], [[3hx0]], [[2pfo]], [[2pfp]], [[2pfq]] - hDpo gamma (mutant) + DNA + nucleotide<br />
**[[8f69]] - mDpo 2 +  DNA - mouse<br />
**[[8f69]] - mDpo gamma2 +  DNA - mouse<br />


*DNA polymerase delta
*DNA polymerase delta


**[[3e0j]] - hDpo 2+3<br />
**[[3e0j]] - hDpo delta2+delta3<br />
**[[3upq]], [[3uq0]], [[3uq2]] - hDpo δ (mutant) + DNA<br />
**[[3upq]], [[3uq0]], [[3uq2]] - hDpo δ (mutant) + DNA<br />
**[[4fo6]] - hDpo δ (mutant) + DNA + nucleotide analog<br />
**[[4fo6]] - hDpo δ (mutant) + DNA + nucleotide analog<br />
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*DNA polymerase epsilon
*DNA polymerase epsilon


**[[5vbn]] - hDpo subunits A+2 <br />
**[[5vbn]] - hDpo epsilon + subunits A+2 <br />
**[[9f6i]], [[9f6j]], [[9f6l]] - hDpo subunit A + DNA – Cryo EM <br />
**[[9f6i]], [[9f6j]], [[9f6l]] - hDpo epsilon subunit A + DNA – Cryo EM <br />
**[[9b8s]], [[9f6e]], [[9f6f]] - hDpo subunit A + DNA + PCNA – Cryo EM <br />
**[[9b8s]], [[9f6e]], [[9f6f]] - hDpo epsilon subunit A + DNA + PCNA – Cryo EM <br />
**[[9b8t]] - hDpo subunit A + DNA + PCNA + nucleotide – Cryo EM <br />
**[[9b8t]] - hDpo epsilon subunit A + DNA + PCNA + nucleotide – Cryo EM <br />


*DNA polymerase zeta
*DNA polymerase zeta


**[[3abd]], [[3abe]] - hDpo catalytic subunit Rev3 + mitotic spindle assembly checkpoint protein Rev7<br />
**[[3abd]], [[3abe]] - hDpo zeta catalytic subunit Rev3 + mitotic spindle assembly checkpoint protein Rev7<br />
**[[6ekm]], [[6bi7]], [[6bcd]], [[6bc8]] - hDpo   catalytic subunit + MAD2B<br />
**[[6ekm]], [[6bi7]], [[6bcd]], [[6bc8]] - hDpo  zeta catalytic subunit + MAD2B<br />
**[[3vu7]], [[4gk0]], [[6ws0]] - hDpo   catalytic subunit + DNA repair protein Rev1 + MAD2B<br />
**[[3vu7]], [[4gk0]], [[6ws0]] - hDpo  zeta catalytic subunit + DNA repair protein Rev1 + MAD2B<br />
**[[6ws5]] - hDpo   catalytic subunit + DNA repair protein Rev1 + MAD2B + inhibitor<br />
**[[6ws5]] - hDpo  zeta catalytic subunit + DNA repair protein Rev1 + MAD2B + inhibitor<br />
**[[4fjo]], [[4gk5]] - hDpo + hDpo   catalytic subunit + DNA repair protein Rev1 + MAD2B<br />
**[[4fjo]], [[4gk5]] - hDpo kappa + hDpo  zeta catalytic subunit + DNA repair protein Rev1 + MAD2B<br />
**[[6v8p]] - hDpo   catalytic subunit + hDpo d subunits 3+small – Cryo EM<br />
**[[6v8p]] - hDpo  zeta catalytic subunit + hDpo d subunits 3+small – Cryo EM<br />
**[[6v93]] - hDpo   catalytic+processivity subunits + hDpo delta subunits 3+small + DNA + dCTP – Cryo EM<br />
**[[6v93]] - hDpo  zeta catalytic+processivity subunits + hDpo delta subunits 3+small + DNA + dCTP – Cryo EM<br />


*DNA polymerase eta or DNA polymerase theta; domains: helicase 1-894; polymerase 1819-2590
*DNA polymerase eta or DNA polymerase theta; domains: helicase 1-894; polymerase 1819-2590


**[[2i5o]] - hDpo ubiquitin-binding zinc finger – NMR<br />
**[[2i5o]] - hDpo eta ubiquitin-binding zinc finger – NMR<br />
**[[3wup]] - hDpo ubiquitin-binding zinc finger <br />
**[[3wup]] - hDpo eta ubiquitin-binding zinc finger <br />
**[[5a9j]] – hDpo helicase domain <br />
**[[5a9j]] – hDpo helicase domain <br />
**[[9asj]], [[9ask]], [[9asl]], [[9bh6]], [[9bh7]] - hDpo - Cryo EM <br />
**[[9asj]], [[9ask]], [[9asl]], [[9bh6]], [[9bh7]] - hDpo eta - Cryo EM <br />
**[[9bp9]], [[9bpa]] - hDpo + inhibitor -  Cryo EM <br />
**[[9bp9]], [[9bpa]] - hDpo eta + inhibitor -  Cryo EM <br />
**[[8ski]], [[8w0a]], [[9bh8]], [[9bh9]], [[9bha]], [[9c5q]] - hDpo helicase domain + DNA - Cryo EM <br />
**[[8ski]], [[8w0a]], [[9bh8]], [[9bh9]], [[9bha]], [[9c5q]] - hDpo eta helicase domain + DNA - Cryo EM <br />
**[[3tq1]], [[4j9k]], [[4j9l]], [[4j9m]], [[4j9n]], [[4j9o]], [[4j9p]], [[4j9q]], [[4j9r]], [[4j9s]], [[6mp3]], [[8eve]], [[8evf]] - hDpo + DNA <br />
**[[3tq1]], [[4j9k]], [[4j9l]], [[4j9m]], [[4j9n]], [[4j9o]], [[4j9p]], [[4j9q]], [[4j9r]], [[4j9s]], [[6mp3]], [[8eve]], [[8evf]] - hDpo eta + DNA <br />
**[[3jaa]], [[3mr2]], [[3mr3]], [[3mr5]], [[3mr6]], [[3si8]], [[4dl2]], [[4dl3]], [[4dl4]], [[4dl5]], [[4dl6]], [[4dl7]], [[4eey]], [[4ecq]], [[4ecr]], [[4ecs]], [[4ect]], [[4ecu]], [[4ecv]], [[4ecw]], [[4ecx]], [[4ecy]], [[4ecz]], [[4ed0]], [[4ed1]], [[4ed2]], [[4ed3]], [[4ed6]], [[4ed7]], [[4ed8]], [[4o3n]], [[4o3o]], [[4o3p]], [[4o3q]], [[4o3r]], [[4o3s]], [[4q8e]], [[4q8f]], [[4rnm]], [[4rnn]], [[4rno]], [[4x0p]], [[4x0q]], [[5l9x]], [[5l1l]], [[5l1k]], [[5l1j]], [[5l1i]], [[5kg7]], [[5kg6]], [[5kg5]], [[5kg4]], [[5kg3]], [[5kg2]], [[5kg1]], [[5kg0]], [[5kfz]], [[5kfy]], [[5kfx]], [[5kfw]], [[5kfv]], [[5kfu]], [[5kft]], [[5kfs]], [[5kfr]], [[5kfq]], [[5kfp]], [[5kfo]], [[5kfn]], [[5kfm]], [[5kfl]], [[5kfk]], [[5kfj]], [[5kfi]], [[5kfh]], [[5kfg]], [[5kff]], [[5kfe]], [[5kfd]], [[5kfc]], [[5kfb]], [[5kfa]], [[5jum]], [[5f9n]], [[5f9l]], [[5ewg]], [[5ewf]], [[5ewe]], [[5dqi]], [[5dqh]], [[5dqg]], [[5dlg]], [[5dlf]], [[5dgb]], [[5dga]], [[5dg9]], [[5dg8]], [[5dg7]], [[4yr3]], [[4yr2]], [[4yr0]], [[4yqw]], [[4yp3]], [[4ru9]], [[6mxo]], [[6m7v]], [[6m7u]], [[6m7t]], [[6m7p]], [[6m7o]], [[6d0z]], [[6d0m]], [[6mq8]], [[6pl7]], [[6pl8]], [[6plc]], [[6ui2]], [[6uqi]], [[6v5k]], [[6w5x]], [[6wk6]], [[7l69]], [[7lcd]], [[7m7l]], [[7m7m]], [[7m7n]], [[7m7o]], [[7m7p]], [[7m7q]], [[7m7r]], [[7m7s]], [[7m7t]], [[7m7u]], [[7m7y]], [[7m7z]], [[7m80]], [[7m81]], [[7m82]], [[7m83]], [[7m84]], [[7m85]], [[7m86]], [[7m87]], [[7m88]], [[7m89]], [[7m8a]], [[7m8b]], [[7m8c]], [[7m8d]], [[7u72]], [[7u73]], [[7u74]], [[7u75]], [[7u76]], [[7u77]], [[7u78]], [[7u79]], [[7u7a]], [[7u7b]], [[7u7c]], [[7u7d]], [[7u7e]], [[7u7g]], [[7u7f]], [[7u7i]], [[7u7j]], [[7u7k]], [[7u7l]], [[7u7r]], [[7u7s]], [[7u7t]], [[7u7u]], [[7u7v]], [[7u7w]], [[7u7x]], [[7u7y]], [[7u7z]], [[7u80]], [[7u81]], [[7u82]], [[7u83]], [[7u84]], [[8e85]], [[8e86]], [[8e87]], [[8e88]], [[8e89]], [[8e8a]], [[8e8c]], [[8e8d]], [[8e8e]], [[8e8f]], [[8e8g]], [[8e8h]], [[8e8j]], [[8e8k]], [[8fn3]], [[8fog]], [[8foh]], [[8foj]], [[8g8h]], [[8g8j]], [[8gbf]], [[8gkr]], [[8gml]], [[8ujt]], [[8ujv]], [[8ujx]], [[8uk4]], [[8v7a]], [[8v7b]], [[8v7c]], [[8v7d]], [[8v7e]], [[8v7f]], [[8v7g]], [[8v7h]], [[8v7j]], [[8v7k]], [[8v7i]], [[9chw]], [[9ci9]], [[9cih]], [[9ciq]] - hDpo + DNA + nucleotide<br />
**[[3jaa]], [[3mr2]], [[3mr3]], [[3mr5]], [[3mr6]], [[3si8]], [[4dl2]], [[4dl3]], [[4dl4]], [[4dl5]], [[4dl6]], [[4dl7]], [[4eey]], [[4ecq]], [[4ecr]], [[4ecs]], [[4ect]], [[4ecu]], [[4ecv]], [[4ecw]], [[4ecx]], [[4ecy]], [[4ecz]], [[4ed0]], [[4ed1]], [[4ed2]], [[4ed3]], [[4ed6]], [[4ed7]], [[4ed8]], [[4o3n]], [[4o3o]], [[4o3p]], [[4o3q]], [[4o3r]], [[4o3s]], [[4q8e]], [[4q8f]], [[4rnm]], [[4rnn]], [[4rno]], [[4x0p]], [[4x0q]], [[5l9x]], [[5l1l]], [[5l1k]], [[5l1j]], [[5l1i]], [[5kg7]], [[5kg6]], [[5kg5]], [[5kg4]], [[5kg3]], [[5kg2]], [[5kg1]], [[5kg0]], [[5kfz]], [[5kfy]], [[5kfx]], [[5kfw]], [[5kfv]], [[5kfu]], [[5kft]], [[5kfs]], [[5kfr]], [[5kfq]], [[5kfp]], [[5kfo]], [[5kfn]], [[5kfm]], [[5kfl]], [[5kfk]], [[5kfj]], [[5kfi]], [[5kfh]], [[5kfg]], [[5kff]], [[5kfe]], [[5kfd]], [[5kfc]], [[5kfb]], [[5kfa]], [[5jum]], [[5f9n]], [[5f9l]], [[5ewg]], [[5ewf]], [[5ewe]], [[5dqi]], [[5dqh]], [[5dqg]], [[5dlg]], [[5dlf]], [[5dgb]], [[5dga]], [[5dg9]], [[5dg8]], [[5dg7]], [[4yr3]], [[4yr2]], [[4yr0]], [[4yqw]], [[4yp3]], [[4ru9]], [[6mxo]], [[6m7v]], [[6m7u]], [[6m7t]], [[6m7p]], [[6m7o]], [[6d0z]], [[6d0m]], [[6mq8]], [[6pl7]], [[6pl8]], [[6plc]], [[6ui2]], [[6uqi]], [[6v5k]], [[6w5x]], [[6wk6]], [[7l69]], [[7lcd]], [[7m7l]], [[7m7m]], [[7m7n]], [[7m7o]], [[7m7p]], [[7m7q]], [[7m7r]], [[7m7s]], [[7m7t]], [[7m7u]], [[7m7y]], [[7m7z]], [[7m80]], [[7m81]], [[7m82]], [[7m83]], [[7m84]], [[7m85]], [[7m86]], [[7m87]], [[7m88]], [[7m89]], [[7m8a]], [[7m8b]], [[7m8c]], [[7m8d]], [[7u72]], [[7u73]], [[7u74]], [[7u75]], [[7u76]], [[7u77]], [[7u78]], [[7u79]], [[7u7a]], [[7u7b]], [[7u7c]], [[7u7d]], [[7u7e]], [[7u7g]], [[7u7f]], [[7u7i]], [[7u7j]], [[7u7k]], [[7u7l]], [[7u7r]], [[7u7s]], [[7u7t]], [[7u7u]], [[7u7v]], [[7u7w]], [[7u7x]], [[7u7y]], [[7u7z]], [[7u80]], [[7u81]], [[7u82]], [[7u83]], [[7u84]], [[8e85]], [[8e86]], [[8e87]], [[8e88]], [[8e89]], [[8e8a]], [[8e8c]], [[8e8d]], [[8e8e]], [[8e8f]], [[8e8g]], [[8e8h]], [[8e8j]], [[8e8k]], [[8fn3]], [[8fog]], [[8foh]], [[8foj]], [[8g8h]], [[8g8j]], [[8gbf]], [[8gkr]], [[8gml]], [[8ujt]], [[8ujv]], [[8ujx]], [[8uk4]], [[8v7a]], [[8v7b]], [[8v7c]], [[8v7d]], [[8v7e]], [[8v7f]], [[8v7g]], [[8v7h]], [[8v7j]], [[8v7k]], [[8v7i]], [[9chw]], [[9ci9]], [[9cih]], [[9ciq]] - hDpo eta + DNA + nucleotide<br />
**[[9au5]], [[9au8]], [[9au9]] - hDpo + DNA + nucleotide – Cryo EM<br />
**[[9au5]], [[9au8]], [[9au9]] - hDpo eta + DNA + nucleotide – Cryo EM<br />
**[[6pz3]], [[6q02]] - hDpo (mutant) + DNA + nucleotide<br />
**[[6pz3]], [[6q02]] - hDpo eta (mutant) + DNA + nucleotide<br />
**[[6xbu]], [[7zus]] – hDpo polymerase domain + nucleotide + DNA<br />
**[[6xbu]], [[7zus]] – hDpo eta polymerase domain + nucleotide + DNA<br />
**[[5a9f]], [[5aga]] - hDpo + nucleotide<br />
**[[5a9f]], [[5aga]] - hDpo eta + nucleotide<br />
**[[7zx0]], [[7zx1]], [[8e23]], [[8e24]] , [[8gd7]]– hDpo polymerase domain + inhibitor + DNA<br />
**[[7zx0]], [[7zx1]], [[8e23]], [[8e24]] , [[8gd7]]– hDpo polymerase domain + inhibitor + DNA<br />
**[[8ef9]], [[8efc]], [[8efk]] – Dpo polymerase domain + nucleotide + DNA – Lates calcarifer<br />
**[[8ef9]], [[8efc]], [[8efk]] – Dpo eta polymerase domain + nucleotide + DNA – Lates calcarifer<br />


*DNA polymerase iota
*DNA polymerase iota

Revision as of 07:36, 27 April 2025

3D Structures of DNA polymerase

Updated on 27-April-2025

6ctq, 6ctp, 6cto, 6ctn, 6ctm, 6ctl, 6ctk, 6ctj, 6cti, 6crh, 6crc, 6crb, 6cr9, 6cr8, 6cr7, 6cr6, 6cr5, 6cr4, 6cr3, 6cpq, 6cly, 6bem, 6bel, 6ph6, 6u2o, 6u6b, 6uok, 6uol, 6uom, 6w2m, 7k96 - hDpo beta + DNA + nucleotide analog

catalytic+2+3+4 + PCNA + DNA + nucleotide analog – Cryo EM

Terminal deoxynucleotidyl transferase binary complex

    • 4iqt, 4iqu, 4iqv, 4iqw – mTdT catalytic domain + inhibitor
    • 4i2i – mTdT catalytic domain + Mg + Zn + adenosine-pentaphosphate
    • 4i2j – mTdT catalytic domain + CTP + Zn
    • 1kej – mTdT catalytic domain + ATP derivative + Co
    • 4i2d – mTdT catalytic domain + ATP derivative + Mg
    • 4i29 – mTdT catalytic domain + AMP derivative + Mn
    • 4i2b – mTdT catalytic domain + AMPCPP + Mg
    • 4i2c – mTdT catalytic domain + AMPCPP + Mn
    • 4i2a – mTdT catalytic domain + UMP derivative + Mg
  • Terminal deoxynucleotidyl transferase ternary complex with DNA
    • 4i2e – mTdT catalytic domain + AMPCPP + Co + DNA
    • 4i2h – mTdT catalytic domain + AMPCPP + Zn + Mg + DNA
    • 4i27 – mTdT catalytic domain + TTP derivative + TMP + Mg + DNA
    • 1kdh – mTdT catalytic domain + UMP derivative + Mg + DNA
    • 4i28, 4i2f – mTdT catalytic domain + Mg + Zn + DNA
    • 4i2g – mTdT catalytic domain + Mg + Co + DNA

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman