Pharmaceutical Drugs

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AstraZeneca’s Nexium
AstraZeneca’s Nexium

The Pharmaceutical industry is one of the world’s largest industries, grossing well over $300 billion in the United States alone. Understanding how the drugs the pharma industry develops work and different characteristics of these compounds is important to nearly everyone as 50% of the US population takes at least one prescription medication regularly and nearly everyone takes a pharmaceutical pill at some point in their life.[1] The following is a growing list of pharmaceutical compounds organized by disorder.

See Pharmaceutical Drug Targets for a list of drug targets organized by disease.

The majority of all modern medicinal drugs target members of the superfamily of proteins called the G protein-coupled receptors or GPCRs[2][3].


The following is a list of pharmaceutical treatments for various diseases, organized by disorder. Each entry highlights general information about the therapeutic, pharmacokinetic data comparisons within its drug class, and a structural analysis explaining how the drug compound functions in vivo.

Alzheimer's Disease

Bacterial Infection


Acetylcholinesterase Inhibitors
Antagonists at glutamatergic NMDA receptors
Macrolide Antibiotics
  • Biaxin: - Generic: Clarithromycin
  • Dynabac - Generic: Dirithromycin
  • Ketek - Generic: Telithromycin
  • Llosone - Generic: Erythromycin
  • Rulide - Generic: Roxithromycin
  • Zithromax - Generic: Azithromycin
  • Invanz (Ertapenem) - Generic: Ertapenem
  • Ciprofloxacin
  • CEN-101
Anti-CD20 Monoclonal Antibody
Anti-melanoma Monoclonal Antibody
B-Raf Kinase Inhibitor
  • Zelboraf - Generic: Vemurafenib (Formerly: PLX-4032)
Dihydrofolate Reductase Inhibitor
  • Alimta - Generic: Pemetrexed
  • Folotyn - Generic: Pralatrexate
  • Methotrexate
  • Raltitrexed
Epidermal Growth Factor Receptor Inhibitor
Estrogen Receptor Modulator
mTOR inhibitor
  • Rapamune - Generic: Sirolimus (Rapamycin)
  • Afinitor - Generic: Everolimus
  • Torisel - Generic: Temsirolimus
Multiple Receptor Tyrosine kinase (VEGFR, PDGFR, EGFR, KIT, Abl) Inhibitor
Vascular Endothelial Growth Factor Inhibitor



Erectile Dysfunction

Serotonin Transporter Inhibitors

Tricyclic Antidepressants
Selective Serotonin Reuptake Inhibitors
Serotonin–norepinephrine reuptake inhibitor

Dipeptidyl peptidase IV Inhibitor
Peroxisome Proliferator-Activated Receptor Agonist
Glucagon-like peptide-1 (GLP-1) agonist
Mechanism is not completely understood
Phosphodiesterase Type 5 Inhibitor
  • Cialis - Generic: Tadalafil
  • Levitra - Generic: Vardenafil
  • Viagra - Generic: Sildenafil




HMG-CoA Reductase Inhibitors (Statins)
Niemann-Pick C1-like 1 (NPC1L1) protein blocker
Angiotensin-Converting Enzyme Inhibitors
β-Adrenergic Receptor Antagonists
  • Betoptic - Generic: Betaxolol
  • Blocadren - Generic: Timolol
  • Bystolic - Generic: Nebivolol
  • Coreg - Generic: Carvedilol
  • Gubernal - Generic: Alprenolol
  • Inderal - Generic: Propranolol
  • Lopressor - Generic: Metroprolol
  • Trandate - Generic: Labetalol
  • Visken - Generic: Pindolol
  • Zebeta - Generic: Bisoprolol
Chemokine Receptor Type 5 (CCR5) Inhibitors
  • Selzentry - Generic: Maraviroc
HIV-Protease Inhibitors
Non-Nucleoside Reverse Transcriptase Inhibitors
  • Intelence - Generic: Etravirine
  • Rescriptor - Generic: Delvirdine
  • Sustiva - Generic: Efavirenz
  • Viramune - Generic: Nevirapine
Nucleoside Analog Reverse Transcriptase Inhibitors
  • Baraclude - Generic: Entecavir
  • Emtriva - Generic: Emtricitabine
  • Epivir - Generic: Lamivudine
  • Hivid - Generic: Zalcitabine
  • Retrovir - Generic: Zidovudine
  • Videx - Generic: Didanosine
  • Viread - Generic: Tenofovir
  • Zerit - Generic: Stavudine
  • Ziagen - Generic: Abacavir
Retroviral Integrase Inhibitors

Inflammation & Arthritis


Opioid drugs

Cyclooxygenase Inhibitors
Phospholipase A2 Inhibitors
  • Voltaren - Generic: Diclofenac also may inhibit phospholipase A2 as part of its mechanism of action.
M2 Proton Channel Inhibitors
Neuraminidase Inhibitors
Opioid receptors agonists
  • MScontin, Oramorph, Sevredol - Generic: Morphine (opioid receptor agonist)
  • Demerol - Generic: Meperidine (opioid receptor agonist)
  • Dolophine - Generic: Methadone (Levomethadone (the R enantiomer) is a opioid receptor agonist)
  • Actiq, Duragesic, Fentora - Generic: Fentanyl (opioid receptor agonist)
Opioid receptors antagonists
  • Narcan - Generic: Naloxone (competitive opioid receptor antagonist)
  • ReVia - Generic: Naltrexone (competitive opioid receptor antagonist)
  • Entereg - Generic: Alvimopan (opioid receptor antagonist)


  2. Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199
  3. Peeters MC, van Westen GJ, Li Q, IJzerman AP. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. PMID:21075459 doi:10.1016/

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